Detailed information of TA system TA044138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3417592..3418253
• Replicon: chromosome
• Accession: NZ_AP027729
• Organism: Paraoerskovia sediminicola strain NBRC 108565

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: QUE47_RS15810
• Protein ID: WP_286218059.1
• Coordinates: 3417825..3418253 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: QUE47_RS15805
• Protein ID: WP_286218058.1
• Coordinates: 3417592..3417828 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE47_RS15785 (GCM10025865_32750)	3412723..3413844	+	1122	WP_286218057.1	glutathione S-transferase C-terminal domain-containing protein	-
QUE47_RS15790 (GCM10025865_32760)	3414334..3415341	+	1008	WP_286219550.1	putative F420-0 ABC transporter substrate-binding protein	-
QUE47_RS15795 (GCM10025865_32770)	3415607..3416593	+	987	WP_286219551.1	iron chelate uptake ABC transporter family permease subunit	-
QUE47_RS15800	3416743..3417506	+	764	Protein_3100	ATP-binding cassette domain-containing protein	-
QUE47_RS15805 (GCM10025865_32790)	3417592..3417828	+	237	WP_286218058.1	YlcI/YnfO family protein	Antitoxin
QUE47_RS15810 (GCM10025865_32800)	3417825..3418253	+	429	WP_286218059.1	PIN domain-containing protein	Toxin
QUE47_RS15815 (GCM10025865_32810)	3418304..3418745	+	442	Protein_3103	VOC family protein	-
QUE47_RS15820 (GCM10025865_32820)	3418914..3419501	-	588	WP_286218060.1	hypothetical protein	-
QUE47_RS15825 (GCM10025865_32830)	3419568..3420161	+	594	WP_286218061.1	HhH-GPD-type base excision DNA repair protein	-
QUE47_RS15830 (GCM10025865_32840)	3420166..3421323	+	1158	WP_286218062.1	2-phospho-L-lactate transferase CofD family protein	-
QUE47_RS15835 (GCM10025865_32850)	3421313..3422062	-	750	WP_286218063.1	2-phospho-L-lactate guanylyltransferase	-
QUE47_RS15840 (GCM10025865_32860)	3422139..3422966	-	828	WP_286218064.1	coenzyme F420-0:L-glutamate ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-133)

Antitoxin

• CopG-like ribbon-helix-helix domain (2-31)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15169.53 Da
• Isoelectric Point: 7.1724

>T44138 WP_286218059.1 NZ_AP027729:3417825-3418253 [Paraoerskovia sediminicola]
MIAPDVTVLVGALVARHPHKHVCEPWLTAAIANPEPLALTDAVLGATVRILTHRRIYPNPLPATAALDLVEGLLAAPGTI
RIGPGPRHWEIFGQLCRGSDVHGNLVADAQHASVAIEHGATWATLDRDFARFPGLRVVDPRA

Nucleotide

• Length: 429 bp

>T44138 NZ_AP027729:3417825-3418253 [Paraoerskovia sediminicola]
ATGATCGCTCCGGACGTCACCGTCCTCGTCGGCGCACTCGTCGCACGCCATCCGCACAAGCACGTGTGCGAGCCGTGGCT
GACCGCGGCGATCGCGAACCCCGAACCGCTCGCTCTCACGGACGCCGTCCTCGGTGCCACGGTGCGGATCCTCACCCACC
GGCGCATCTACCCGAACCCGCTGCCCGCCACTGCCGCGCTCGACCTCGTCGAGGGCCTGCTGGCCGCACCGGGGACCATC
CGGATCGGGCCGGGGCCGCGCCACTGGGAGATCTTCGGGCAGCTCTGCCGGGGCTCCGACGTCCACGGAAACCTGGTCGC
CGACGCACAGCACGCCTCCGTCGCGATCGAGCACGGCGCGACGTGGGCGACGCTCGACCGGGACTTCGCCCGGTTCCCCG
GTCTGCGCGTCGTCGACCCGCGCGCCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.88 Da
• Isoelectric Point: 4.7683

>AT44138 WP_286218058.1 NZ_AP027729:3417592-3417828 [Paraoerskovia sediminicola]
MRTTLHLPDDLYRDVKRTAAQEGRTVTSLVEDALREELRRRTAAPGRPYVVPTVDLGDPLVEIDMTSNAAMLDAMDGR

Nucleotide

• Length: 237 bp

>AT44138 NZ_AP027729:3417592-3417828 [Paraoerskovia sediminicola]
ATGAGGACCACTCTGCACCTGCCCGACGACCTCTACCGGGACGTCAAGCGCACCGCCGCGCAGGAGGGACGCACCGTCAC
GTCGCTCGTCGAGGACGCGCTGCGCGAAGAGCTGCGCAGGCGGACCGCCGCTCCCGGTCGGCCGTACGTCGTCCCGACCG
TCGACCTCGGAGACCCCCTCGTCGAGATCGACATGACGAGCAACGCCGCGATGCTCGACGCGATGGACGGCCGATGA