Detailed information of TA system TA044137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2411818..2412320
• Replicon: chromosome
• Accession: NZ_AP027729
• Organism: Paraoerskovia sediminicola strain NBRC 108565

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: QUE47_RS11195
• Protein ID: WP_286217355.1
• Coordinates: 2412063..2412320 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: QUE47_RS11190
• Protein ID: WP_286217354.1
• Coordinates: 2411818..2412066 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE47_RS11170 (GCM10025865_23010)	2406958..2407662	-	705	WP_286217350.1	phosphotransferase	-
QUE47_RS11175 (GCM10025865_23020)	2408300..2409562	+	1263	WP_286217351.1	cysteine desulfurase family protein	-
QUE47_RS11180 (GCM10025865_23030)	2409562..2410743	+	1182	WP_286217352.1	tRNA 2-thiouridine(34) synthase MnmA	-
QUE47_RS11185 (GCM10025865_23040)	2410740..2411765	+	1026	WP_286217353.1	hypothetical protein	-
QUE47_RS11190 (GCM10025865_23050)	2411818..2412066	+	249	WP_286217354.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
QUE47_RS11195 (GCM10025865_23060)	2412063..2412320	+	258	WP_286217355.1	Txe/YoeB family addiction module toxin	Toxin
QUE47_RS11200 (GCM10025865_23080)	2412354..2414671	-	2318	Protein_2201	prolyl oligopeptidase family serine peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10287.57 Da
• Isoelectric Point: 8.0035

>T44137 WP_286217355.1 NZ_AP027729:2412063-2412320 [Paraoerskovia sediminicola]
VNIVFAPQAWDDYTYWQTQDRATLKRVTRLIDDICREPYEGIGKPERLRYGVEAWSRRISDEHRIVYRVEGSNVLVLQAR
YHYER

Nucleotide

• Length: 258 bp

>T44137 NZ_AP027729:2412063-2412320 [Paraoerskovia sediminicola]
GTGAACATCGTCTTCGCGCCCCAGGCGTGGGACGACTACACCTACTGGCAGACGCAGGACCGTGCGACGCTCAAGCGGGT
CACCCGGCTGATCGACGACATCTGCCGTGAACCGTACGAGGGGATCGGCAAGCCGGAGCGGCTGCGCTACGGGGTGGAGG
CGTGGTCCCGCCGGATCAGTGACGAGCACCGGATCGTCTACCGGGTCGAGGGGTCGAACGTGCTGGTCCTCCAGGCGCGC
TACCACTACGAGCGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8972.06 Da
• Isoelectric Point: 4.4488

>AT44137 WP_286217354.1 NZ_AP027729:2411818-2412066 [Paraoerskovia sediminicola]
MAITASEARKTLFPLIEQVNDDHTAVEITSKRGNAILVSVEEFEALTETAYLFRSPANARRLLDADEALRTGNGIPAELD
RG

Nucleotide

• Length: 249 bp

>AT44137 NZ_AP027729:2411818-2412066 [Paraoerskovia sediminicola]
ATGGCCATCACGGCGAGCGAAGCGCGCAAGACCCTGTTCCCGCTCATCGAGCAGGTGAACGACGACCACACCGCGGTCGA
GATCACGTCCAAGCGCGGCAACGCGATCCTGGTCTCGGTCGAGGAGTTCGAGGCGCTGACCGAGACCGCCTACCTCTTCC
GGTCGCCCGCCAACGCGCGCAGGCTGCTCGACGCGGACGAGGCCCTGAGGACCGGGAACGGCATCCCCGCGGAGCTGGAC
CGCGGGTGA