Detailed information of TA system TA044136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1319269..1319903
• Replicon: chromosome
• Accession: NZ_AP027729
• Organism: Paraoerskovia sediminicola strain NBRC 108565

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: QUE47_RS06285
• Protein ID: WP_286219053.1
• Coordinates: 1319496..1319903 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: QUE47_RS06280
• Protein ID: WP_286219052.1
• Coordinates: 1319269..1319499 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE47_RS06255 (GCM10025865_12760)	1314302..1315603	+	1302	WP_286219047.1	dipeptidase	-
QUE47_RS06260 (GCM10025865_12770)	1315713..1316561	+	849	WP_286219048.1	ATP-binding cassette domain-containing protein	-
QUE47_RS06265 (GCM10025865_12780)	1316558..1317292	+	735	WP_286219049.1	ABC transporter permease	-
QUE47_RS06270 (GCM10025865_12790)	1317289..1318029	+	741	WP_286219050.1	ABC transporter permease	-
QUE47_RS06275 (GCM10025865_12800)	1318083..1319048	+	966	WP_286219051.1	ABC transporter substrate-binding protein	-
QUE47_RS06280 (GCM10025865_12810)	1319269..1319499	+	231	WP_286219052.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
QUE47_RS06285 (GCM10025865_12820)	1319496..1319903	+	408	WP_286219053.1	type II toxin-antitoxin system VapC family toxin	Toxin
QUE47_RS06290 (GCM10025865_12830)	1319893..1320438	-	546	WP_286219054.1	YbaK/EbsC family protein	-
QUE47_RS06295 (GCM10025865_12840)	1320509..1321069	-	561	WP_286219055.1	hypothetical protein	-
QUE47_RS06300 (GCM10025865_12850)	1321135..1322118	-	984	WP_286219056.1	aldo/keto reductase	-
QUE47_RS06305 (GCM10025865_12860)	1322265..1323974	-	1710	WP_286219057.1	phosphoenolpyruvate--protein phosphotransferase	-
QUE47_RS06310	1323989..1324257	-	269	Protein_1242	HPr family phosphocarrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (6-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14876.96 Da
• Isoelectric Point: 5.6855

>T44136 WP_286219053.1 NZ_AP027729:1319496-1319903 [Paraoerskovia sediminicola]
VTTLYLLDTNILIALLRRRADAARPRLRAAEGRIAVSTISEAELDYGIERSRHAEQNRQAVDELLSLVEVVPFDSTAAMH
AGRVRAVLADRGEPIGPYDTLLAGHARSLGLVMVTNNVREFSRVPGLEVEDWLSC

Nucleotide

• Length: 408 bp

>T44136 NZ_AP027729:1319496-1319903 [Paraoerskovia sediminicola]
GTGACGACGCTCTACCTGCTCGACACCAACATCCTCATCGCGCTCCTGCGCAGACGCGCCGATGCGGCCCGTCCGAGGCT
CCGCGCGGCCGAGGGACGCATCGCGGTCTCGACGATCAGCGAGGCAGAGCTGGACTACGGGATCGAGCGCTCCCGGCACG
CCGAGCAGAACCGTCAGGCGGTCGACGAGCTGCTGAGCCTTGTGGAGGTCGTACCGTTCGACTCGACCGCAGCGATGCAT
GCCGGCCGGGTCCGTGCGGTCCTCGCCGACCGGGGAGAGCCGATCGGGCCGTACGACACGCTCCTCGCCGGTCACGCACG
GTCGCTCGGCCTGGTCATGGTGACGAACAACGTCCGGGAGTTCTCGCGAGTGCCAGGACTCGAAGTCGAGGACTGGCTCA
GCTGCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8436.48 Da
• Isoelectric Point: 5.7906

>AT44136 WP_286219052.1 NZ_AP027729:1319269-1319499 [Paraoerskovia sediminicola]
MRTTVFLNNRTQAVRLPKALALPDGTREVNVRAVGRSRVIEPVGSSWDGWFEHGPFAADDFLVDRDQGVAEERAAL

Nucleotide

• Length: 231 bp

>AT44136 NZ_AP027729:1319269-1319499 [Paraoerskovia sediminicola]
ATGAGAACCACAGTGTTTCTCAACAACCGCACGCAGGCGGTGCGCCTGCCCAAGGCGCTCGCCCTGCCCGACGGCACCCG
CGAGGTCAACGTCCGCGCGGTCGGCCGCTCGCGCGTGATCGAGCCGGTCGGTTCGTCGTGGGACGGCTGGTTCGAGCACG
GCCCGTTCGCCGCCGACGACTTTCTCGTCGACCGCGACCAGGGCGTCGCCGAAGAGCGCGCGGCTCTGTGA