Detailed information of TA system TA044135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 11440..12101
• Replicon: chromosome
• Accession: NZ_AP027729
• Organism: Paraoerskovia sediminicola strain NBRC 108565

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: QUE47_RS00070
• Protein ID: WP_286218059.1
• Coordinates: 11673..12101 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: QUE47_RS00065
• Protein ID: WP_286218058.1
• Coordinates: 11440..11676 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE47_RS00045 (GCM10025865_00060)	6572..7693	+	1122	WP_286218057.1	glutathione S-transferase C-terminal domain-containing protein	-
QUE47_RS00050 (GCM10025865_00070)	8183..9190	+	1008	WP_286219550.1	putative F420-0 ABC transporter substrate-binding protein	-
QUE47_RS00055	9456..10441	+	986	Protein_10	iron chelate uptake ABC transporter family permease subunit	-
QUE47_RS00060	10591..11354	+	764	Protein_11	ATP-binding cassette domain-containing protein	-
QUE47_RS00065 (GCM10025865_00100)	11440..11676	+	237	WP_286218058.1	YlcI/YnfO family protein	Antitoxin
QUE47_RS00070 (GCM10025865_00110)	11673..12101	+	429	WP_286218059.1	PIN domain-containing protein	Toxin
QUE47_RS00075 (GCM10025865_00120)	12152..12594	+	443	Protein_14	VOC family protein	-
QUE47_RS00080	12591..12686	+	96	Protein_15	Fe-S cluster assembly protein HesB	-
QUE47_RS00085 (GCM10025865_00130)	12763..13350	-	588	WP_286218060.1	hypothetical protein	-
QUE47_RS00090 (GCM10025865_00140)	13417..14010	+	594	WP_286218061.1	HhH-GPD-type base excision DNA repair protein	-
QUE47_RS00095 (GCM10025865_00150)	14015..15172	+	1158	WP_286218062.1	2-phospho-L-lactate transferase CofD family protein	-
QUE47_RS00100 (GCM10025865_00160)	15162..15911	-	750	WP_286218063.1	2-phospho-L-lactate guanylyltransferase	-
QUE47_RS00105 (GCM10025865_00170)	15988..16815	-	828	WP_286218064.1	coenzyme F420-0:L-glutamate ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-133)

Antitoxin

• CopG-like ribbon-helix-helix domain (2-31)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15169.53 Da
• Isoelectric Point: 7.1724

>T44135 WP_286218059.1 NZ_AP027729:11673-12101 [Paraoerskovia sediminicola]
MIAPDVTVLVGALVARHPHKHVCEPWLTAAIANPEPLALTDAVLGATVRILTHRRIYPNPLPATAALDLVEGLLAAPGTI
RIGPGPRHWEIFGQLCRGSDVHGNLVADAQHASVAIEHGATWATLDRDFARFPGLRVVDPRA

Nucleotide

• Length: 429 bp

>T44135 NZ_AP027729:11673-12101 [Paraoerskovia sediminicola]
ATGATCGCTCCGGACGTCACCGTCCTCGTCGGCGCACTCGTCGCACGCCATCCGCACAAGCACGTGTGCGAGCCGTGGCT
GACCGCGGCGATCGCGAACCCCGAACCGCTCGCTCTCACGGACGCCGTCCTCGGTGCCACGGTGCGGATCCTCACCCACC
GGCGCATCTACCCGAACCCGCTGCCCGCCACTGCCGCGCTCGACCTCGTCGAGGGCCTGCTGGCCGCACCGGGGACCATC
CGGATCGGGCCGGGGCCGCGCCACTGGGAGATCTTCGGGCAGCTCTGCCGGGGCTCCGACGTCCACGGAAACCTGGTCGC
CGACGCACAGCACGCCTCCGTCGCGATCGAGCACGGCGCGACGTGGGCGACGCTCGACCGGGACTTCGCCCGGTTCCCCG
GTCTGCGCGTCGTCGACCCGCGCGCCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.88 Da
• Isoelectric Point: 4.7683

>AT44135 WP_286218058.1 NZ_AP027729:11440-11676 [Paraoerskovia sediminicola]
MRTTLHLPDDLYRDVKRTAAQEGRTVTSLVEDALREELRRRTAAPGRPYVVPTVDLGDPLVEIDMTSNAAMLDAMDGR

Nucleotide

• Length: 237 bp

>AT44135 NZ_AP027729:11440-11676 [Paraoerskovia sediminicola]
ATGAGGACCACTCTGCACCTGCCCGACGACCTCTACCGGGACGTCAAGCGCACCGCCGCGCAGGAGGGACGCACCGTCAC
GTCGCTCGTCGAGGACGCGCTGCGCGAAGAGCTGCGCAGGCGGACCGCCGCTCCCGGTCGGCCGTACGTCGTCCCGACCG
TCGACCTCGGAGACCCCCTCGTCGAGATCGACATGACGAGCAACGCCGCGATGCTCGACGCGATGGACGGCCGATGA