Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2179579..2180153 Replicon chromosome
Accession NZ_AP027728
Organism Microbacterium suwonense strain NBRC 106310

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QUE33_RS10850 Protein ID WP_286299919.1
Coordinates 2179579..2179941 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QUE33_RS10855 Protein ID WP_286299921.1
Coordinates 2179938..2180153 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE33_RS10825 (GCM10025863_22590) 2175324..2175620 + 297 WP_286299911.1 N-acetyltransferase -
QUE33_RS10830 (GCM10025863_22600) 2175784..2176329 + 546 WP_286299913.1 ECF transporter S component -
QUE33_RS10835 (GCM10025863_22610) 2176462..2178123 + 1662 WP_286299914.1 energy-coupling factor transporter ATPase -
QUE33_RS10840 2178120..2178951 + 832 Protein_2117 energy-coupling factor transporter transmembrane component T -
QUE33_RS10845 (GCM10025863_22630) 2178973..2179533 + 561 WP_286299917.1 ECF transporter S component -
QUE33_RS10850 (GCM10025863_22640) 2179579..2179941 - 363 WP_286299919.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QUE33_RS10855 (GCM10025863_22650) 2179938..2180153 - 216 WP_286299921.1 ribbon-helix-helix domain-containing protein Antitoxin
QUE33_RS10860 (GCM10025863_22660) 2180215..2181378 - 1164 WP_286299924.1 acyl-CoA dehydrogenase family protein -
QUE33_RS10865 (GCM10025863_22670) 2181546..2182472 - 927 WP_286299925.1 M15 family metallopeptidase -
QUE33_RS10870 2182557..2183608 + 1052 Protein_2123 Rv2578c family radical SAM protein -
QUE33_RS10875 (GCM10025863_22690) 2183658..2183843 - 186 WP_286299926.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-119)

Antitoxin

Antitoxin ParD

(6-45)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 12599.55 Da        Isoelectric Point: 11.3253

>T44133 WP_286299919.1 NZ_AP027728:c2179941-2179579 [Microbacterium suwonense]
MISLLRRGQIVVVALDPAVGSEAKKTRPAVVVSNNTANAAAARSDRATVTVVPLTSNASRVLPFQVHLPAGETGLDRDTK
AQAEQVRTVAVSRIVRPVGWVGSELMGALDEALRLHLALG

Download         Length: 363 bp

>T44133 NZ_AP027728:c2179941-2179579 [Microbacterium suwonense]
ATGATCTCCCTGCTGCGGCGGGGGCAGATCGTCGTGGTGGCGTTGGACCCCGCCGTCGGCTCCGAGGCGAAGAAGACCCG
ACCGGCCGTGGTGGTGAGTAACAACACCGCGAATGCGGCGGCCGCACGCAGCGATCGCGCGACCGTCACCGTGGTCCCGC
TCACCTCGAACGCATCGCGCGTGCTGCCCTTCCAAGTGCACCTCCCCGCCGGTGAGACCGGATTGGATCGTGACACGAAG
GCCCAGGCGGAGCAGGTGCGCACGGTCGCGGTATCTCGCATCGTCCGCCCGGTGGGATGGGTCGGCTCTGAGCTGATGGG
CGCACTCGACGAGGCGCTTCGTCTGCATCTCGCGCTCGGCTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7744.43 Da        Isoelectric Point: 3.9566

>AT44133 WP_286299921.1 NZ_AP027728:c2180153-2179938 [Microbacterium suwonense]
MSHSKISLSLSDADLAFLDAEALQGRYASRSAAVQDAVRMLRESRLADAYAEAYAEGYDEDWDTAIEDGIA

Download         Length: 216 bp

>AT44133 NZ_AP027728:c2180153-2179938 [Microbacterium suwonense]
ATGTCGCACAGCAAGATCAGTCTGAGTCTGAGCGATGCCGATCTCGCATTCCTCGACGCGGAGGCTCTGCAGGGCCGTTA
TGCGTCGAGGTCGGCCGCCGTTCAGGATGCGGTGCGGATGCTGCGCGAGAGTCGTCTTGCGGATGCCTATGCCGAGGCCT
ACGCAGAGGGCTATGACGAGGACTGGGACACGGCGATCGAGGACGGGATCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References