Detailed information of TA system TA044132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 6062304..6063300
• Replicon: chromosome
• Accession: NZ_AP027452
• Organism: Mycolicibacterium mageritense strain H4_3_1

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: QUE81_RS29365
• Protein ID: WP_073912033.1
• Coordinates: 6062722..6063300 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: QUE81_RS29360
• Protein ID: WP_286212070.1
• Coordinates: 6062304..6062693 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE81_RS29345 (hbim_05879)	6058052..6058798	-	747	WP_036442353.1	alpha/beta hydrolase	-
QUE81_RS29350 (hbim_05880)	6059013..6060314	+	1302	WP_286212067.1	TrpB-like pyridoxal phosphate-dependent enzyme	-
QUE81_RS29355 (hbim_05881)	6060331..6062184	-	1854	WP_286212068.1	serine/threonine-protein kinase	-
QUE81_RS29360 (hbim_05882)	6062304..6062693	+	390	WP_286212070.1	hypothetical protein	Antitoxin
QUE81_RS29365 (hbim_05883)	6062722..6063300	+	579	WP_073912033.1	zeta toxin family protein	Toxin
QUE81_RS29370 (hbim_05884)	6063216..6064697	-	1482	WP_081812839.1	cytosine permease	-
QUE81_RS29375 (hbim_05885)	6064871..6066541	+	1671	WP_286212072.1	biotin carboxylase	-
QUE81_RS29380 (hbim_05886)	6066635..6068143	+	1509	WP_286212073.1	PucR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 20862.69 Da
• Isoelectric Point: 8.5195

>T44132 WP_073912033.1 NZ_AP027452:6062722-6063300 [Mycolicibacterium mageritense]
VKRLDLVVGSNGAGKSTFVELTLGPLLPNSPFVNADEIAKRRWPEDPATHSYEAARIAAQTRARLIERGDSFIAETVFSH
PSKLDLIDTANTAGYSVILHVVMIPEDLAVLRVRHRVEAGGHDVPEAKIRERYQRLWPLVAAAAARSESATFYDNSTTKG
PRIVAQVTGGFVVGSPAWPNWTPAALVSTWPG

Nucleotide

• Length: 579 bp

>T44132 NZ_AP027452:6062722-6063300 [Mycolicibacterium mageritense]
GTGAAGCGGCTCGACCTCGTCGTCGGATCCAACGGCGCGGGCAAGTCGACGTTCGTCGAACTCACGCTCGGGCCCCTGTT
GCCCAACAGTCCTTTCGTCAACGCCGACGAGATCGCCAAGCGCCGCTGGCCCGAGGATCCCGCCACCCACTCTTATGAGG
CCGCACGTATCGCGGCGCAAACCCGGGCCAGGCTCATCGAGCGGGGCGATTCGTTCATCGCCGAAACCGTGTTCTCCCAC
CCGTCCAAACTGGACCTGATAGACACCGCGAACACGGCCGGCTACAGCGTCATCCTGCACGTCGTGATGATCCCGGAGGA
TCTCGCGGTGCTGCGCGTGCGACACCGTGTCGAGGCGGGTGGTCACGATGTCCCAGAAGCGAAGATTCGTGAACGCTACC
AACGGCTCTGGCCGCTCGTCGCCGCCGCGGCGGCGCGCTCGGAATCGGCGACGTTCTATGACAACAGCACCACGAAGGGC
CCCCGCATCGTGGCTCAGGTCACGGGCGGTTTCGTCGTGGGGTCACCGGCCTGGCCGAATTGGACACCGGCCGCGCTGGT
GTCGACGTGGCCAGGGTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13816.29 Da
• Isoelectric Point: 4.9265

>AT44132 WP_286212070.1 NZ_AP027452:6062304-6062693 [Mycolicibacterium mageritense]
MTDTADRVTRFAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSRQSAARRKVEAALAGDTPLRDLTVEEGVVFNAEI
SAAIEENLARADYGTTLAARGVTTVALDDNGEIVQYRPDGSTTVLVPQR

Nucleotide

• Length: 390 bp

>AT44132 NZ_AP027452:6062304-6062693 [Mycolicibacterium mageritense]
ATGACTGACACCGCAGACCGCGTGACTCGGTTCGCCGCTGATCTGATGGACAGCGCTGCCGCGGAAGGCGCGCGCCAGAG
CCGCTCGGCCAAGCAACAGCTCGACCACTGGGCGCGTGTCGGACGGGCCGTGTCAAGCCGGCAGAGCGCCGCACGCCGCA
AGGTCGAGGCAGCCTTGGCGGGCGACACCCCGTTGCGTGATCTGACCGTCGAGGAGGGCGTCGTGTTCAACGCCGAGATC
TCCGCGGCCATCGAGGAGAACCTGGCGCGCGCCGATTACGGCACGACACTGGCCGCCCGTGGGGTCACCACCGTCGCGCT
CGACGACAACGGCGAGATCGTGCAGTACCGCCCTGATGGCAGCACCACGGTGTTGGTGCCTCAGCGGTGA