Detailed information of TA system TA044131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2039442..2039986
• Replicon: chromosome
• Accession: NZ_AP027452
• Organism: Mycolicibacterium mageritense strain H4_3_1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: QUE81_RS10180
• Protein ID: WP_286214663.1
• Coordinates: 2039442..2039738 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: X5KR67
• Locus tag: QUE81_RS10185
• Protein ID: WP_036430692.1
• Coordinates: 2039735..2039986 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE81_RS10155 (hbim_02040)	2036182..2036625	+	444	WP_286214654.1	roadblock/LC7 domain-containing protein	-
QUE81_RS10160 (hbim_02041)	2036625..2037002	+	378	WP_286214656.1	DUF742 domain-containing protein	-
QUE81_RS10165 (hbim_02042)	2036983..2037567	+	585	WP_036430697.1	ATP/GTP-binding protein	-
QUE81_RS10170 (hbim_02043)	2037590..2038372	+	783	WP_286214659.1	MHYT domain-containing protein	-
QUE81_RS10175 (hbim_02044)	2038436..2039431	+	996	WP_286214661.1	glycoside hydrolase family 6 protein	-
QUE81_RS10180 (hbim_02045)	2039442..2039738	-	297	WP_286214663.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUE81_RS10185 (hbim_02046)	2039735..2039986	-	252	WP_036430692.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
QUE81_RS10190 (hbim_02047)	2040281..2042113	+	1833	WP_286214666.1	hypothetical protein	-
QUE81_RS10195 (hbim_02048)	2042209..2043237	+	1029	WP_286214668.1	fused (3R)-hydroxyacyl-ACP dehydratase subunits HadA/HadB	-
QUE81_RS10200 (hbim_02049)	2043248..2044024	-	777	WP_286214670.1	helix-turn-helix transcriptional regulator	-
QUE81_RS10205 (hbim_02050)	2044115..2044807	+	693	WP_286214672.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (2-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11496.06 Da
• Isoelectric Point: 6.2206

>T44131 WP_286214663.1 NZ_AP027452:c2039738-2039442 [Mycolicibacterium mageritense]
VSRYVLSPAARADLESIWDYTCERWDIKQAEEYVREIQLAVERIVAYPMIGRACDDVRPGYRKHAVGSHTLYYRIGGGDM
VDVVRILHQRMDVDRYFD

Nucleotide

• Length: 297 bp

>T44131 NZ_AP027452:c2039738-2039442 [Mycolicibacterium mageritense]
GTGAGTCGTTATGTCCTTTCACCCGCTGCGCGTGCGGACCTGGAATCAATCTGGGATTACACGTGTGAACGATGGGACAT
CAAGCAGGCGGAGGAATACGTCCGTGAAATCCAGCTCGCGGTCGAACGTATCGTCGCGTATCCCATGATCGGACGGGCGT
GCGACGACGTCCGCCCCGGATACCGCAAGCACGCTGTCGGATCCCATACGCTGTACTACCGGATCGGCGGTGGCGACATG
GTTGACGTTGTGCGCATCCTCCACCAACGAATGGACGTGGACCGGTACTTCGACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9520.52 Da
• Isoelectric Point: 5.9008

>AT44131 WP_036430692.1 NZ_AP027452:c2039986-2039735 [Mycolicibacterium mageritense]
VGKNTSFSLDEHFSSFIEEEVASGRYRSASDVVRTALRLLEDRETRLRALRRELIAGERSGESTPFDFDQFIAGKRTEEP
RAR

Nucleotide

• Length: 252 bp

>AT44131 NZ_AP027452:c2039986-2039735 [Mycolicibacterium mageritense]
GTGGGTAAGAACACGTCATTCAGCCTCGACGAGCATTTCAGCTCTTTCATCGAGGAGGAGGTCGCATCGGGCCGGTACCG
CTCGGCCAGCGATGTCGTTCGTACAGCACTGCGACTGCTGGAGGACCGTGAGACCCGCCTGCGGGCATTGCGTCGGGAAC
TCATCGCCGGTGAACGAAGCGGCGAATCAACACCGTTCGACTTCGATCAATTCATCGCGGGCAAGCGAACTGAAGAACCC
CGCGCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: X5KR67