Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1844473..1845304 | Replicon | chromosome |
| Accession | NZ_AP027445 | ||
| Organism | Escherichia coli strain EC291 isolate EC291 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | QUE55_RS10705 | Protein ID | WP_000854814.1 |
| Coordinates | 1844473..1844847 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | QUE55_RS10710 | Protein ID | WP_032339188.1 |
| Coordinates | 1844936..1845304 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE55_RS10665 (1839869) | 1839869..1841035 | + | 1167 | WP_025670459.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| QUE55_RS10670 (1841154) | 1841154..1841627 | + | 474 | WP_001105415.1 | DNA gyrase inhibitor SbmC | - |
| QUE55_RS10675 (1841825) | 1841825..1842883 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| QUE55_RS10680 (1843055) | 1843055..1843384 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| QUE55_RS10685 (1843485) | 1843485..1843619 | - | 135 | WP_001297944.1 | EutP/PduV family microcompartment system protein | - |
| QUE55_RS10690 (1843739) | 1843739..1843867 | + | 129 | Protein_1784 | transposase domain-containing protein | - |
| QUE55_RS10695 (1844156) | 1844156..1844236 | - | 81 | Protein_1785 | hypothetical protein | - |
| QUE55_RS10700 (1844282) | 1844282..1844476 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| QUE55_RS10705 (1844473) | 1844473..1844847 | - | 375 | WP_000854814.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| QUE55_RS10710 (1844936) | 1844936..1845304 | - | 369 | WP_032339188.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| QUE55_RS10715 (1845378) | 1845378..1845599 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| QUE55_RS10720 (1845662) | 1845662..1846138 | - | 477 | WP_123010363.1 | RadC family protein | - |
| QUE55_RS10725 (1846154) | 1846154..1846633 | - | 480 | WP_000860076.1 | antirestriction protein | - |
| QUE55_RS10730 (1846715) | 1846715..1847536 | - | 822 | WP_001234530.1 | DUF932 domain-containing protein | - |
| QUE55_RS10735 (1847809) | 1847809..1849350 | + | 1542 | WP_032339187.1 | IS21-like element ISEc12 family transposase | - |
| QUE55_RS10740 (1849365) | 1849365..1850111 | + | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| QUE55_RS10745 (1850196) | 1850196..1850303 | - | 108 | Protein_1795 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T44112 WP_000854814.1 NZ_AP027445:c1844847-1844473 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T44112 NZ_AP027445:c1844847-1844473 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13627.50 Da Isoelectric Point: 6.3139
>AT44112 WP_032339188.1 NZ_AP027445:c1845304-1844936 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTFSSCGYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTFSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT44112 NZ_AP027445:c1845304-1844936 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCTTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCTTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|