Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 46570..47071 | Replicon | plasmid pEC291_2 |
| Accession | NZ_AP027443 | ||
| Organism | Escherichia coli strain EC291 isolate EC291 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | QUE55_RS00895 | Protein ID | WP_000702247.1 |
| Coordinates | 46811..47071 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | QUE55_RS00890 | Protein ID | WP_001132407.1 |
| Coordinates | 46570..46821 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE55_RS00850 (MUTS14_01580) | 41627..42379 | + | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
| QUE55_RS00855 (MUTS14_01590) | 42381..43088 | + | 708 | WP_021503228.1 | hypothetical protein | - |
| QUE55_RS00860 (MUTS14_01600) | 43108..43434 | + | 327 | WP_063078684.1 | hypothetical protein | - |
| QUE55_RS00865 (MUTS14_01610) | 43565..44002 | - | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| QUE55_RS00870 (MUTS14_01620) | 44027..44209 | - | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| QUE55_RS00875 (MUTS14_01630) | 44506..44949 | + | 444 | WP_000068545.1 | hypothetical protein | - |
| QUE55_RS00880 (MUTS14_01640) | 45056..45322 | - | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| QUE55_RS00885 (MUTS14_01660) | 45742..46020 | - | 279 | WP_000545938.1 | hypothetical protein | - |
| QUE55_RS00890 (MUTS14_01670) | 46570..46821 | - | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| QUE55_RS00895 (MUTS14_01680) | 46811..47071 | - | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| QUE55_RS00900 (MUTS14_01690) | 47123..47347 | - | 225 | WP_000814381.1 | hypothetical protein | - |
| QUE55_RS00905 (MUTS14_01700) | 47444..47653 | - | 210 | WP_000866036.1 | hypothetical protein | - |
| QUE55_RS00910 (MUTS14_01710) | 47695..48018 | - | 324 | WP_000427403.1 | hypothetical protein | - |
| QUE55_RS00915 | 48345..48491 | + | 147 | WP_001356709.1 | hypothetical protein | - |
| QUE55_RS00920 (MUTS14_01720) | 48600..48929 | - | 330 | WP_000855120.1 | hypothetical protein | - |
| QUE55_RS00925 (MUTS14_01730) | 49527..50192 | + | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| QUE55_RS00930 (MUTS14_01740) | 50266..50550 | + | 285 | WP_001162371.1 | hypothetical protein | - |
| QUE55_RS00935 (MUTS14_01750) | 50568..51164 | - | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| QUE55_RS00940 | 51314..51436 | - | 123 | WP_223170659.1 | type I toxin-antitoxin system Hok family toxin | - |
| QUE55_RS00945 (MUTS14_01760) | 51381..51533 | - | 153 | Protein_62 | DUF5431 family protein | - |
| QUE55_RS00950 | 51859..52020 | - | 162 | WP_001128311.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60733 | 60733 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T44101 WP_000702247.1 NZ_AP027443:c47071-46811 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T44101 NZ_AP027443:c47071-46811 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT44101 WP_001132407.1 NZ_AP027443:c46821-46570 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT44101 NZ_AP027443:c46821-46570 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|