Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 42709..43244 | Replicon | plasmid pB27_1 |
| Accession | NZ_AP027425 | ||
| Organism | Escherichia coli strain B27 isolate B27 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q3YTD6 |
| Locus tag | QUE78_RS23315 | Protein ID | WP_000222766.1 |
| Coordinates | 42709..42996 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0VIP2 |
| Locus tag | QUE78_RS23320 | Protein ID | WP_001132900.1 |
| Coordinates | 42993..43244 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE78_RS23285 (38115) | 38115..38819 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| QUE78_RS23290 (38856) | 38856..39824 | - | 969 | WP_235927900.1 | DUF4158 domain-containing protein | - |
| QUE78_RS23295 (39805) | 39805..40428 | - | 624 | WP_000904945.1 | recombinase family protein | - |
| QUE78_RS23300 (40679) | 40679..41878 | + | 1200 | Protein_45 | Tn3 family transposase | - |
| QUE78_RS23305 (41912) | 41912..42412 | + | 501 | Protein_46 | Tn3 family transposase | - |
| QUE78_RS23310 (42446) | 42446..42634 | + | 189 | Protein_47 | IS3 family transposase | - |
| QUE78_RS23315 (42709) | 42709..42996 | - | 288 | WP_000222766.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE78_RS23320 (42993) | 42993..43244 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| QUE78_RS23325 (44210) | 44210..45067 | - | 858 | WP_039002220.1 | incFII family plasmid replication initiator RepA | - |
| QUE78_RS23330 (45060) | 45060..45134 | - | 75 | WP_061357229.1 | RepA leader peptide Tap | - |
| QUE78_RS23335 (45366) | 45366..45623 | - | 258 | WP_001541895.1 | replication regulatory protein RepA | - |
| QUE78_RS23340 (45891) | 45891..46040 | - | 150 | WP_001312851.1 | Hok/Gef family protein | - |
| - (46084) | 46084..46145 | + | 62 | NuclAT_2 | - | - |
| - (46084) | 46084..46145 | + | 62 | NuclAT_2 | - | - |
| - (46084) | 46084..46145 | + | 62 | NuclAT_2 | - | - |
| - (46084) | 46084..46145 | + | 62 | NuclAT_2 | - | - |
| QUE78_RS23345 (46487) | 46487..46699 | - | 213 | WP_001541896.1 | ANR family transcriptional regulator | - |
| QUE78_RS23350 (46834) | 46834..47394 | - | 561 | WP_000139310.1 | fertility inhibition protein FinO | - |
| QUE78_RS23355 (47449) | 47449..48192 | - | 744 | WP_039002216.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCMY-2 / aac(3)-IId / mcr-3.1 / mph(A) | - | 1..133820 | 133820 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11147.23 Da Isoelectric Point: 10.5832
>T43994 WP_000222766.1 NZ_AP027425:c42996-42709 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
Download Length: 288 bp
>T43994 NZ_AP027425:c42996-42709 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9211.41 Da Isoelectric Point: 4.0780
>AT43994 WP_001132900.1 NZ_AP027425:c43244-42993 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
Download Length: 252 bp
>AT43994 NZ_AP027425:c43244-42993 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CDZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0VIP2 |