Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2303927..2304762 Replicon chromosome
Accession NZ_AP027417
Organism Escherichia coli strain EC361 isolate EC361

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8S7S8K0
Locus tag QUF17_RS14665 Protein ID WP_000854723.1
Coordinates 2303927..2304304 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7S6L8
Locus tag QUF17_RS14670 Protein ID WP_001285573.1
Coordinates 2304394..2304762 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUF17_RS14635 (2299567) 2299567..2301408 + 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -
QUF17_RS14640 (2301486) 2301486..2301992 - 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
QUF17_RS14650 (2302291) 2302291..2303136 - 846 WP_001290254.1 DUF4942 domain-containing protein -
QUF17_RS14655 (2303233) 2303233..2303430 - 198 WP_000772035.1 DUF957 domain-containing protein -
QUF17_RS14660 (2303442) 2303442..2303930 - 489 WP_000761669.1 DUF5983 family protein -
QUF17_RS14665 (2303927) 2303927..2304304 - 378 WP_000854723.1 TA system toxin CbtA family protein Toxin
QUF17_RS14670 (2304394) 2304394..2304762 - 369 WP_001285573.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QUF17_RS14675 (2304842) 2304842..2305063 - 222 WP_000692176.1 DUF987 domain-containing protein -
QUF17_RS14680 (2305150) 2305150..2305626 - 477 WP_001360063.1 RadC family protein -
QUF17_RS14685 (2305642) 2305642..2306136 - 495 WP_032167345.1 antirestriction protein -
QUF17_RS14690 (2306228) 2306228..2307046 - 819 WP_032167344.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14145.23 Da        Isoelectric Point: 8.2904

>T43889 WP_000854723.1 NZ_AP027417:c2304304-2303927 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRTRRATGLMARDNYRTVNNIILGKHPGAKQ

Download         Length: 378 bp

>T43889 NZ_AP027417:c2304304-2303927 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGACCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTATCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13585.33 Da        Isoelectric Point: 6.3159

>AT43889 WP_001285573.1 NZ_AP027417:c2304762-2304394 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCSVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT43889 NZ_AP027417:c2304762-2304394 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCTCCGTGAC
GCCCTGTTTCGGTGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References