Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 4809263..4809734 | Replicon | chromosome |
| Accession | NZ_AP027411 | ||
| Organism | Escherichia coli strain EC521 isolate EC521 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | QUE69_RS24195 | Protein ID | WP_001303511.1 |
| Coordinates | 4809456..4809734 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | QUE69_RS24190 | Protein ID | WP_001302048.1 |
| Coordinates | 4809263..4809454 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE69_RS24150 (4804782) | 4804782..4805042 | - | 261 | WP_063082130.1 | hypothetical protein | - |
| QUE69_RS24155 (4805060) | 4805060..4805515 | - | 456 | WP_001151173.1 | DUF977 family protein | - |
| QUE69_RS24160 (4805532) | 4805532..4806302 | - | 771 | WP_000450698.1 | DUF1627 domain-containing protein | - |
| QUE69_RS24165 (4806325) | 4806325..4807071 | - | 747 | WP_000788975.1 | ATP-binding protein | - |
| QUE69_RS24170 (4807078) | 4807078..4808025 | - | 948 | WP_063082131.1 | helix-turn-helix domain-containing protein | - |
| QUE69_RS24175 (4808049) | 4808049..4808474 | - | 426 | WP_000693861.1 | toxin YdaT family protein | - |
| QUE69_RS24180 (4808471) | 4808471..4808773 | - | 303 | WP_000172735.1 | transcriptional regulator | - |
| QUE69_RS24185 (4808871) | 4808871..4809242 | + | 372 | WP_001169685.1 | hypothetical protein | - |
| QUE69_RS24190 (4809263) | 4809263..4809454 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| QUE69_RS24195 (4809456) | 4809456..4809734 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE69_RS24200 (4810087) | 4810087..4810386 | + | 300 | WP_044502262.1 | hypothetical protein | - |
| QUE69_RS24205 (4810458) | 4810458..4810676 | + | 219 | WP_001171939.1 | protein YdfC | - |
| QUE69_RS24210 (4810699) | 4810699..4811106 | + | 408 | WP_000394519.1 | hypothetical protein | - |
| QUE69_RS24215 (4811084) | 4811084..4811317 | - | 234 | WP_000920491.1 | hypothetical protein | - |
| QUE69_RS24220 (4811878) | 4811878..4812066 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| QUE69_RS24225 (4812063) | 4812063..4812254 | + | 192 | WP_001083273.1 | lysis protein YdfD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4787751..4823405 | 35654 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T43861 WP_001303511.1 NZ_AP027411:4809456-4809734 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43861 NZ_AP027411:4809456-4809734 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGCTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGCTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43861 WP_001302048.1 NZ_AP027411:4809263-4809454 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43861 NZ_AP027411:4809263-4809454 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|