Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4329370..4329896 | Replicon | chromosome |
| Accession | NZ_AP027411 | ||
| Organism | Escherichia coli strain EC521 isolate EC521 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QUE69_RS21645 | Protein ID | WP_000323025.1 |
| Coordinates | 4329609..4329896 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QUE69_RS21640 | Protein ID | WP_000534858.1 |
| Coordinates | 4329370..4329609 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE69_RS21605 (4324484) | 4324484..4324735 | + | 252 | Protein_4057 | DUF977 family protein | - |
| QUE69_RS21610 (4324732) | 4324732..4325221 | + | 490 | Protein_4058 | SAM-dependent methyltransferase | - |
| QUE69_RS21615 (4325699) | 4325699..4326120 | + | 422 | Protein_4059 | hypothetical protein | - |
| QUE69_RS21620 (4326776) | 4326776..4327846 | + | 1071 | Protein_4060 | ISNCY family transposase | - |
| QUE69_RS21625 (4327919) | 4327919..4328068 | + | 150 | WP_011443592.1 | protein YdfW | - |
| QUE69_RS21630 (4328505) | 4328505..4328837 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| QUE69_RS21635 (4329040) | 4329040..4329345 | - | 306 | WP_213831558.1 | protein YdfV | - |
| QUE69_RS21640 (4329370) | 4329370..4329609 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QUE69_RS21645 (4329609) | 4329609..4329896 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QUE69_RS21650 (4329968) | 4329968..4330123 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QUE69_RS21655 (4330340) | 4330340..4330591 | + | 252 | WP_000980994.1 | protein Rem | - |
| QUE69_RS21660 (4330658) | 4330658..4330936 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| QUE69_RS21665 (4330938) | 4330938..4331987 | + | 1050 | WP_286356161.1 | DUF968 domain-containing protein | - |
| QUE69_RS21670 (4332001) | 4332001..4332753 | + | 753 | WP_001047135.1 | antitermination protein | - |
| QUE69_RS21675 (4333031) | 4333031..4333120 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| QUE69_RS21680 (4333175) | 4333175..4333387 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QUE69_RS21685 (4333688) | 4333688..4333903 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| QUE69_RS21690 (4334267) | 4334267..4334437 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| QUE69_RS21695 (4334657) | 4334657..4334872 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4309118..4345026 | 35908 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43858 WP_000323025.1 NZ_AP027411:4329609-4329896 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43858 NZ_AP027411:4329609-4329896 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43858 WP_000534858.1 NZ_AP027411:4329370-4329609 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43858 NZ_AP027411:4329370-4329609 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|