Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 51957..52479 | Replicon | plasmid pEC521_1 |
| Accession | NZ_AP027410 | ||
| Organism | Escherichia coli strain EC521 isolate EC521 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | QUE69_RS00600 | Protein ID | WP_000638823.1 |
| Coordinates | 51957..52238 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | QUE69_RS00605 | Protein ID | WP_000121741.1 |
| Coordinates | 52228..52479 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE69_RS00565 (MUTS4_01150) | 48106..48426 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| QUE69_RS00570 (MUTS4_01160) | 48497..48787 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| QUE69_RS00575 (MUTS4_01170) | 48787..49371 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| QUE69_RS00580 (MUTS4_01180) | 49392..49790 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| QUE69_RS00585 (MUTS4_01190) | 49909..50346 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| QUE69_RS00590 (MUTS4_01200) | 50352..51587 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| QUE69_RS00595 (MUTS4_01210) | 51590..51889 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| QUE69_RS00600 (MUTS4_01220) | 51957..52238 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE69_RS00605 (MUTS4_01230) | 52228..52479 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| QUE69_RS00610 | 52579..53214 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| QUE69_RS00615 (MUTS4_01240) | 53287..53574 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| QUE69_RS00620 (MUTS4_01250) | 53587..53841 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| QUE69_RS00625 (MUTS4_01260) | 53843..54484 | - | 642 | WP_001425343.1 | type IV secretion system protein | - |
| QUE69_RS00630 (MUTS4_01270) | 54490..55485 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| QUE69_RS00635 (MUTS4_01280) | 55489..55746 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| QUE69_RS00640 (MUTS4_01290) | 55743..56045 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| QUE69_RS00645 | 56026..56283 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| QUE69_RS00650 (MUTS4_01300) | 56316..56762 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| QUE69_RS00655 (MUTS4_01310) | 56773..56943 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| QUE69_RS00660 (MUTS4_01320) | 56947..57390 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60712 | 60712 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T43840 WP_000638823.1 NZ_AP027410:c52238-51957 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T43840 NZ_AP027410:c52238-51957 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT43840 WP_000121741.1 NZ_AP027410:c52479-52228 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT43840 NZ_AP027410:c52479-52228 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|