Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 106363..107198 | Replicon | chromosome |
| Accession | NZ_AP027408 | ||
| Organism | Escherichia coli strain EC507 isolate EC507 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2Y8M938 |
| Locus tag | QUE45_RS01610 | Protein ID | WP_047661875.1 |
| Coordinates | 106363..106740 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A2Y0C7M1 |
| Locus tag | QUE45_RS01615 | Protein ID | WP_047661876.1 |
| Coordinates | 106830..107198 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE45_RS01590 (103399) | 103399..104835 | - | 1437 | WP_286343051.1 | EAL domain-containing protein | - |
| QUE45_RS01595 (105014) | 105014..105859 | - | 846 | WP_286343052.1 | DUF4942 domain-containing protein | - |
| QUE45_RS01600 (105944) | 105944..106141 | - | 198 | WP_087891818.1 | DUF957 domain-containing protein | - |
| QUE45_RS01605 (106169) | 106169..106366 | - | 198 | Protein_96 | DUF5983 family protein | - |
| QUE45_RS01610 (106363) | 106363..106740 | - | 378 | WP_047661875.1 | TA system toxin CbtA family protein | Toxin |
| QUE45_RS01615 (106830) | 106830..107198 | - | 369 | WP_047661876.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QUE45_RS01620 (107248) | 107248..107892 | - | 645 | WP_047661877.1 | hypothetical protein | - |
| QUE45_RS01625 (107907) | 107907..108128 | - | 222 | WP_047661878.1 | DUF987 domain-containing protein | - |
| QUE45_RS01630 (108197) | 108197..108673 | - | 477 | WP_041124171.1 | RadC family protein | - |
| QUE45_RS01635 (108689) | 108689..109174 | - | 486 | WP_073527669.1 | antirestriction protein | - |
| QUE45_RS01640 (109265) | 109265..110083 | - | 819 | WP_089180129.1 | DUF932 domain-containing protein | - |
| QUE45_RS01645 (110183) | 110183..110416 | - | 234 | WP_123001125.1 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 93580..126999 | 33419 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14195.18 Da Isoelectric Point: 8.8867
>T43813 WP_047661875.1 NZ_AP027408:c106740-106363 [Escherichia coli]
MKTSPDTHVREASCCPSPVTIWQTLLSRLLDQHYGLTLNNTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQFINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR
MKTSPDTHVREASCCPSPVTIWQTLLSRLLDQHYGLTLNNTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQFINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR
Download Length: 378 bp
>T43813 NZ_AP027408:c106740-106363 [Escherichia coli]
ATGAAAACATCACCCGATACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATAACACTCCATTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTCTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCCGGGTTC
AGCACTTGTCCCCGCTCTCAGTTCATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGTCTGATGACCCGCAG
CCACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATCACCCGATACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATAACACTCCATTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTCTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCCCTGGTGCGTACCGACCAGCCCGGGTTC
AGCACTTGTCCCCGCTCTCAGTTCATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCAACAGGTCTGATGACCCGCAG
CCACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13660.30 Da Isoelectric Point: 5.4561
>AT43813 WP_047661876.1 NZ_AP027408:c107198-106830 [Escherichia coli]
VSDSLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKT
VSDSLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKT
Download Length: 369 bp
>AT43813 NZ_AP027408:c107198-106830 [Escherichia coli]
GTGTCAGACTCGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA
GTGTCAGACTCGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAACGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2Y8M938 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2Y0C7M1 |