Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 53220..53742 | Replicon | plasmid pEC507_2 |
| Accession | NZ_AP027406 | ||
| Organism | Escherichia coli strain EC507 isolate EC507 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | QUE45_RS00610 | Protein ID | WP_000638823.1 |
| Coordinates | 53220..53501 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | QUE45_RS00615 | Protein ID | WP_000121741.1 |
| Coordinates | 53491..53742 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE45_RS00575 (MUTS3_01180) | 49369..49689 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| QUE45_RS00580 (MUTS3_01190) | 49760..50050 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| QUE45_RS00585 (MUTS3_01200) | 50050..50634 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| QUE45_RS00590 (MUTS3_01210) | 50655..51053 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| QUE45_RS00595 (MUTS3_01220) | 51172..51609 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| QUE45_RS00600 (MUTS3_01230) | 51615..52850 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| QUE45_RS00605 (MUTS3_01240) | 52853..53152 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| QUE45_RS00610 (MUTS3_01250) | 53220..53501 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE45_RS00615 (MUTS3_01260) | 53491..53742 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| QUE45_RS00620 | 53842..54477 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| QUE45_RS00625 (MUTS3_01270) | 54550..54837 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| QUE45_RS00630 (MUTS3_01280) | 54850..55104 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| QUE45_RS00635 (MUTS3_01290) | 55106..55747 | - | 642 | WP_001425343.1 | type IV secretion system protein | - |
| QUE45_RS00640 (MUTS3_01300) | 55753..56748 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| QUE45_RS00645 (MUTS3_01310) | 56752..57009 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| QUE45_RS00650 (MUTS3_01320) | 57006..57308 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| QUE45_RS00655 | 57289..57546 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| QUE45_RS00660 (MUTS3_01330) | 57579..58025 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| QUE45_RS00665 (MUTS3_01340) | 58036..58206 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| QUE45_RS00670 (MUTS3_01350) | 58210..58653 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61975 | 61975 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T43808 WP_000638823.1 NZ_AP027406:c53501-53220 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T43808 NZ_AP027406:c53501-53220 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT43808 WP_000121741.1 NZ_AP027406:c53742-53491 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT43808 NZ_AP027406:c53742-53491 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|