Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3007053..3007579 | Replicon | chromosome |
| Accession | NZ_AP027404 | ||
| Organism | Escherichia coli strain EC416 isolate EC416 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QUE37_RS15640 | Protein ID | WP_000323025.1 |
| Coordinates | 3007292..3007579 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QUE37_RS15635 | Protein ID | WP_000534858.1 |
| Coordinates | 3007053..3007292 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE37_RS15600 (3002167) | 3002167..3002418 | + | 252 | Protein_2850 | DUF977 family protein | - |
| QUE37_RS15605 (3002415) | 3002415..3002904 | + | 490 | Protein_2851 | class I SAM-dependent methyltransferase | - |
| QUE37_RS15610 (3003382) | 3003382..3003803 | + | 422 | Protein_2852 | hypothetical protein | - |
| QUE37_RS15615 (3004459) | 3004459..3005481 | + | 1023 | Protein_2853 | ISNCY family transposase | - |
| QUE37_RS15620 (3005602) | 3005602..3005751 | + | 150 | WP_011443592.1 | protein YdfW | - |
| QUE37_RS15625 (3006188) | 3006188..3006520 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| QUE37_RS15630 (3006723) | 3006723..3007028 | - | 306 | WP_001326990.1 | protein YdfV | - |
| QUE37_RS15635 (3007053) | 3007053..3007292 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QUE37_RS15640 (3007292) | 3007292..3007579 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QUE37_RS15645 (3007651) | 3007651..3007806 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QUE37_RS15650 (3008023) | 3008023..3008274 | + | 252 | WP_000980994.1 | protein Rem | - |
| QUE37_RS15655 (3008341) | 3008341..3008619 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| QUE37_RS15660 (3008621) | 3008621..3009670 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| QUE37_RS15665 (3009684) | 3009684..3010436 | + | 753 | WP_001047135.1 | antitermination protein | - |
| QUE37_RS15670 (3010714) | 3010714..3010803 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| QUE37_RS15675 (3010858) | 3010858..3011070 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QUE37_RS15680 (3011371) | 3011371..3011586 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| QUE37_RS15685 (3011950) | 3011950..3012120 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| QUE37_RS15690 (3012340) | 3012340..3012555 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2993394..3033244 | 39850 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43801 WP_000323025.1 NZ_AP027404:3007292-3007579 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43801 NZ_AP027404:3007292-3007579 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43801 WP_000534858.1 NZ_AP027404:3007053-3007292 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43801 NZ_AP027404:3007053-3007292 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|