Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 52977..53499 | Replicon | plasmid pEC416_2 |
| Accession | NZ_AP027402 | ||
| Organism | Escherichia coli strain EC416 isolate EC416 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | QUE37_RS00305 | Protein ID | WP_000638823.1 |
| Coordinates | 52977..53258 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | QUE37_RS00310 | Protein ID | WP_000121741.1 |
| Coordinates | 53248..53499 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE37_RS00270 (MUTS2_00550) | 49126..49446 | - | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
| QUE37_RS00275 (MUTS2_00560) | 49517..49807 | - | 291 | WP_000865479.1 | conjugal transfer protein | - |
| QUE37_RS00280 (MUTS2_00570) | 49807..50391 | - | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| QUE37_RS00285 (MUTS2_00580) | 50412..50810 | - | 399 | WP_001153665.1 | hypothetical protein | - |
| QUE37_RS00290 (MUTS2_00590) | 50929..51366 | - | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| QUE37_RS00295 (MUTS2_00600) | 51372..52607 | - | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| QUE37_RS00300 (MUTS2_00610) | 52610..52909 | - | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| QUE37_RS00305 (MUTS2_00620) | 52977..53258 | - | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE37_RS00310 (MUTS2_00630) | 53248..53499 | - | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| QUE37_RS00315 | 53599..54234 | - | 636 | WP_015059536.1 | hypothetical protein | - |
| QUE37_RS00320 (MUTS2_00640) | 54307..54594 | - | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| QUE37_RS00325 (MUTS2_00650) | 54607..54861 | - | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| QUE37_RS00330 (MUTS2_00660) | 54863..55504 | - | 642 | WP_001425343.1 | type IV secretion system protein | - |
| QUE37_RS00335 (MUTS2_00670) | 55510..56505 | - | 996 | WP_001028543.1 | type IV secretion system protein | - |
| QUE37_RS00340 (MUTS2_00680) | 56509..56766 | - | 258 | WP_000739144.1 | hypothetical protein | - |
| QUE37_RS00345 (MUTS2_00690) | 56763..57065 | - | 303 | WP_001360345.1 | hypothetical protein | - |
| QUE37_RS00350 | 57046..57303 | - | 258 | WP_001542015.1 | hypothetical protein | - |
| QUE37_RS00355 (MUTS2_00700) | 57336..57782 | - | 447 | WP_001243165.1 | hypothetical protein | - |
| QUE37_RS00360 (MUTS2_00710) | 57793..57963 | - | 171 | WP_000550720.1 | hypothetical protein | - |
| QUE37_RS00365 (MUTS2_00720) | 57967..58410 | - | 444 | WP_000964330.1 | NfeD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61732 | 61732 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T43780 WP_000638823.1 NZ_AP027402:c53258-52977 [Escherichia coli]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T43780 NZ_AP027402:c53258-52977 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT43780 WP_000121741.1 NZ_AP027402:c53499-53248 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT43780 NZ_AP027402:c53499-53248 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|