Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 7032..7533 | Replicon | plasmid pEC416_2 |
| Accession | NZ_AP027402 | ||
| Organism | Escherichia coli strain EC416 isolate EC416 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | QUE37_RS00060 | Protein ID | WP_000702247.1 |
| Coordinates | 7032..7292 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | QUE37_RS00065 | Protein ID | WP_001132407.1 |
| Coordinates | 7282..7533 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE37_RS00015 (MUTS2_00030) | 2570..2722 | + | 153 | Protein_2 | DUF5431 family protein | - |
| QUE37_RS00020 | 2667..2789 | + | 123 | WP_223170659.1 | type I toxin-antitoxin system Hok family toxin | - |
| QUE37_RS00025 (MUTS2_00040) | 2939..3535 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| QUE37_RS00030 (MUTS2_00050) | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| QUE37_RS00035 (MUTS2_00060) | 3911..4576 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| QUE37_RS00040 (MUTS2_00070) | 5174..5503 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| QUE37_RS00045 (MUTS2_00080) | 6085..6408 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| QUE37_RS00050 (MUTS2_00090) | 6450..6659 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| QUE37_RS00055 (MUTS2_00100) | 6756..6980 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| QUE37_RS00060 (MUTS2_00110) | 7032..7292 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| QUE37_RS00065 (MUTS2_00120) | 7282..7533 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| QUE37_RS00070 (MUTS2_00130) | 8083..8361 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| QUE37_RS00075 (MUTS2_00150) | 8780..9046 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| QUE37_RS00080 (MUTS2_00160) | 9153..9596 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| QUE37_RS00085 (MUTS2_00170) | 9893..10075 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| QUE37_RS00090 (MUTS2_00180) | 10100..10537 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| QUE37_RS00095 (MUTS2_00190) | 10668..10994 | - | 327 | WP_063078684.1 | hypothetical protein | - |
| QUE37_RS00100 (MUTS2_00200) | 11014..11721 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| QUE37_RS00105 (MUTS2_00210) | 11723..12475 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61732 | 61732 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T43779 WP_000702247.1 NZ_AP027402:7032-7292 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T43779 NZ_AP027402:7032-7292 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT43779 WP_001132407.1 NZ_AP027402:7282-7533 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT43779 NZ_AP027402:7282-7533 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|