Detailed information of TA system TA043774

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2207184..2207728
• Replicon: chromosome
• Accession: NZ_AP027365
• Organism: Thalassotalea sp. PTE2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: QUE72_RS09665
• Protein ID: WP_286268699.1
• Coordinates: 2207184..2207483 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Q6CHA5
• Locus tag: QUE72_RS09670
• Protein ID: WP_074498930.1
• Coordinates: 2207471..2207728 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE72_RS09640	2203030..2203362	-	333	Protein_1878	putative sulfate exporter family transporter	-
QUE72_RS09645	2203374..2203706	+	333	WP_286272966.1	LysR substrate-binding domain-containing protein	-
QUE72_RS09650	2203712..2204755	-	1044	WP_286272967.1	serine hydrolase domain-containing protein	-
QUE72_RS09655	2204918..2205238	-	321	WP_074498932.1	hypothetical protein	-
QUE72_RS09660	2205939..2206904	+	966	WP_286268698.1	type II CAAX endopeptidase family protein	-
QUE72_RS09665	2207184..2207483	-	300	WP_286268699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUE72_RS09670	2207471..2207728	-	258	WP_074498930.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
QUE72_RS09675	2207803..2208150	-	348	WP_286268702.1	hypothetical protein	-
QUE72_RS09680	2208180..2209622	-	1443	WP_286268704.1	amidohydrolase family protein	-
QUE72_RS09685	2209976..2210950	-	975	WP_286268706.1	transposase	-
QUE72_RS09690	2211072..2211338	-	267	Protein_1888	transposase	-
QUE72_RS09695	2211418..2211999	-	582	WP_286268707.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11710.49 Da
• Isoelectric Point: 8.0442

>T43774 WP_286268699.1 NZ_AP027365:c2207483-2207184 [Thalassotalea sp. PTE2]
MAEVIWTSSALDDLNEIAEYIALSNLSAAKKLTQKVFDKISRLENHPESGKRPHELMNLNYREMNINPCRIFYKVDSDKV
YILHVMRQERDLRRFLLQS

Nucleotide

• Length: 300 bp

>T43774 NZ_AP027365:c2207483-2207184 [Thalassotalea sp. PTE2]
ATGGCTGAAGTAATATGGACTTCCTCAGCCCTAGATGATTTAAACGAGATCGCTGAATATATTGCTTTAAGTAATCTTTC
TGCTGCAAAAAAGTTGACTCAGAAAGTATTTGATAAAATATCTAGATTAGAAAATCATCCTGAATCTGGTAAAAGACCAC
ATGAATTGATGAACTTAAATTATCGTGAAATGAATATTAATCCTTGTCGTATTTTTTATAAAGTGGATAGCGACAAAGTT
TATATTTTACATGTTATGCGACAAGAACGCGATCTACGCAGGTTTCTTTTACAGAGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9717.15 Da
• Isoelectric Point: 6.4701

>AT43774 WP_074498930.1 NZ_AP027365:c2207728-2207471 [Thalassotalea sp. PTE2]
MRVELVTTLKRQATKILADLHTSKEPVLITEHGQPSAYLVDVEDYEFMQQRLAILEGVARGEQAIKNGETFSNQEAKEKM
SKWLK

Nucleotide

• Length: 258 bp

>AT43774 NZ_AP027365:c2207728-2207471 [Thalassotalea sp. PTE2]
ATGAGAGTTGAACTTGTAACAACACTTAAACGGCAAGCTACTAAAATTCTAGCTGACCTACATACATCAAAAGAACCCGT
ACTGATAACTGAACATGGTCAACCATCTGCTTACTTAGTTGATGTAGAAGATTATGAGTTTATGCAACAGAGATTGGCTA
TTCTTGAAGGTGTAGCACGCGGTGAGCAAGCAATTAAAAATGGTGAAACTTTCTCAAATCAAGAAGCAAAAGAGAAAATG
AGTAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q6CHA5