Detailed information of TA system TA043773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 726221..726753
• Replicon: chromosome
• Accession: NZ_AP027365
• Organism: Thalassotalea sp. PTE2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: QUE72_RS03095
• Protein ID: WP_286271478.1
• Coordinates: 726221..726514 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: QUE72_RS03100
• Protein ID: WP_286271480.1
• Coordinates: 726514..726753 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE72_RS03085	722171..722815	-	645	WP_286271475.1	hypothetical protein	-
QUE72_RS03090	723044..725989	+	2946	WP_286271477.1	tetratricopeptide repeat protein	-
QUE72_RS03095	726221..726514	-	294	WP_286271478.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUE72_RS03100	726514..726753	-	240	WP_286271480.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
QUE72_RS03105	726882..728074	+	1193	WP_286269112.1	IS3 family transposase	-
QUE72_RS03110	728550..729775	-	1226	Protein_608	IS110 family transposase	-
QUE72_RS03115	729906..730133	+	228	WP_286271481.1	DUF6429 family protein	-
QUE72_RS03120	730182..731132	-	951	Protein_610	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11249.02 Da
• Isoelectric Point: 9.5041

>T43773 WP_286271478.1 NZ_AP027365:c726514-726221 [Thalassotalea sp. PTE2]
MNKFVLSAKAKTDLIKIAKYTQITWGLSQRNDYLKVLDSTFHLLAGEPELGINCDYIREGYSKYPQASHVIYYKEYKNSQ
IFIVRILHKSMDVNSAL

Nucleotide

• Length: 294 bp

>T43773 NZ_AP027365:c726514-726221 [Thalassotalea sp. PTE2]
ATGAATAAGTTTGTATTATCTGCGAAAGCCAAAACAGACTTAATTAAAATAGCTAAATATACCCAAATTACTTGGGGACT
ATCTCAACGGAATGATTACCTAAAAGTATTAGATAGTACATTCCATTTATTAGCTGGTGAACCCGAACTAGGCATTAACT
GTGATTATATTAGAGAGGGCTACAGTAAATACCCACAAGCTAGTCATGTGATCTATTACAAAGAGTATAAAAACAGCCAA
ATATTTATCGTGCGAATATTGCATAAAAGTATGGATGTAAACTCCGCACTCTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8843.77 Da
• Isoelectric Point: 4.5007

>AT43773 WP_286271480.1 NZ_AP027365:c726753-726514 [Thalassotalea sp. PTE2]
MAKNTSVTLGDHFDQFINQQLNTGRYGSASEIVRAGLRALEDQEAKLLNLRNMLIQGEQSGVAEYSYESLLTDLDKDNH

Nucleotide

• Length: 240 bp

>AT43773 NZ_AP027365:c726753-726514 [Thalassotalea sp. PTE2]
ATGGCTAAAAATACAAGCGTAACACTAGGCGATCATTTTGATCAGTTTATAAACCAACAACTTAACACTGGTCGTTATGG
CTCAGCAAGTGAAATTGTTAGAGCTGGATTAAGAGCTTTAGAAGATCAAGAAGCTAAGCTGTTAAATTTACGCAATATGT
TAATCCAAGGCGAACAAAGCGGTGTTGCTGAGTACAGTTATGAAAGCTTATTGACTGATTTAGATAAAGATAACCATTAA