Detailed information of TA system TA043772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 532868..533406
• Replicon: chromosome
• Accession: NZ_AP027365
• Organism: Thalassotalea sp. PTE2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: QUE72_RS02265
• Protein ID: WP_286271255.1
• Coordinates: 532868..533158 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1Q6CI04
• Locus tag: QUE72_RS02270
• Protein ID: WP_074498770.1
• Coordinates: 533143..533406 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE72_RS02250	530350..531450	-	1101	WP_286271250.1	efflux RND transporter periplasmic adaptor subunit	-
QUE72_RS02255	531549..532214	+	666	WP_286271252.1	TetR/AcrR family transcriptional regulator	-
QUE72_RS02265	532868..533158	-	291	WP_286271255.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUE72_RS02270	533143..533406	-	264	WP_074498770.1	CopG family ribbon-helix-helix protein	Antitoxin
QUE72_RS02280	534062..535246	+	1185	WP_286271258.1	alpha/beta hydrolase-fold protein	-
QUE72_RS02285	535797..536714	+	918	WP_286271260.1	mechanosensitive ion channel family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11000.70 Da
• Isoelectric Point: 10.3703

>T43772 WP_286271255.1 NZ_AP027365:c533158-532868 [Thalassotalea sp. PTE2]
MSREVVWLPDAVTDLMRLRKFIQEKNPNAAKRAASKIKEGALTLMSNPESGRPVEGLSSFREILIPFGTGNYVLRYREEN
ITIAVVRVWHSKEERT

Nucleotide

• Length: 291 bp

>T43772 NZ_AP027365:c533158-532868 [Thalassotalea sp. PTE2]
ATGTCCCGAGAAGTAGTTTGGTTACCTGATGCCGTAACAGATTTAATGCGGTTGAGAAAGTTCATTCAAGAGAAAAACCC
AAACGCAGCTAAAAGAGCAGCAAGCAAGATAAAAGAAGGTGCATTAACTTTAATGAGTAACCCTGAATCAGGACGCCCTG
TTGAAGGCTTAAGCTCATTTCGAGAAATACTCATTCCTTTTGGCACAGGAAATTATGTTTTACGTTATAGGGAGGAGAAC
ATTACTATCGCTGTTGTAAGGGTGTGGCACAGCAAAGAAGAACGTACTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10076.06 Da
• Isoelectric Point: 4.6708

>AT43772 WP_074498770.1 NZ_AP027365:c533406-533143 [Thalassotalea sp. PTE2]
MLGVRLDDDLESRLSALAERTHRSKSHHAKEALARYIEQEEAKELADKESLERWEAYKENGESVSNQSVMNWLEGWGTEQ
EKSCPEK

Nucleotide

• Length: 264 bp

>AT43772 NZ_AP027365:c533406-533143 [Thalassotalea sp. PTE2]
ATGTTAGGCGTTAGATTAGATGATGACTTAGAAAGTAGGTTGTCTGCATTGGCAGAACGTACCCATCGTTCAAAAAGTCA
TCATGCCAAAGAAGCATTAGCCCGTTATATCGAGCAAGAAGAAGCGAAAGAGTTAGCTGATAAAGAATCATTAGAAAGAT
GGGAAGCTTATAAAGAAAATGGTGAGTCTGTTAGTAATCAATCAGTAATGAATTGGTTAGAGGGTTGGGGTACTGAGCAG
GAAAAATCATGTCCCGAGAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1Q6CI04