Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3592995..3594595 Replicon chromosome
Accession NZ_AP027362
Organism Thalassotalea piscium strain JCM 18590

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QUD79_RS15970 Protein ID WP_184423720.1
Coordinates 3592995..3594326 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QUD79_RS15975 Protein ID WP_184423719.1
Coordinates 3594326..3594595 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD79_RS15965 3590459..3592357 - 1899 WP_184423721.1 class I SAM-dependent methyltransferase -
QUD79_RS15970 3592995..3594326 - 1332 WP_184423720.1 type II toxin-antitoxin system HipA family toxin Toxin
QUD79_RS15975 3594326..3594595 - 270 WP_184423719.1 helix-turn-helix transcriptional regulator Antitoxin
QUD79_RS15980 3594776..3594976 - 201 WP_184423718.1 Arm DNA-binding domain-containing protein -
QUD79_RS15985 3595570..3595860 + 291 WP_184423717.1 helix-turn-helix transcriptional regulator -
QUD79_RS15990 3595850..3597214 + 1365 WP_184423716.1 type II toxin-antitoxin system HipA family toxin -
QUD79_RS15995 3597227..3598231 + 1005 WP_184423715.1 SEC-C domain-containing protein -
QUD79_RS16000 3598242..3599360 + 1119 WP_184423714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49723.15 Da        Isoelectric Point: 7.1733

>T43767 WP_184423720.1 NZ_AP027362:c3594326-3592995 [Thalassotalea piscium]
MAKRKVSALTIWMNAEFVGTWRIKSGVDELQYAEEWLENPRGRPLSLSLPFTPGNQPIKGDIVSFYFDNLLPDSRDIRDR
LARRFSTASTKVFDLLVELGRDCVGAIQLLPEGEKPQNIKQIQYKPLNEQQVAGILNKAVDTYPLGRLDDDDELRISLAG
AQEKTALLWHNNQWCEPLGETPTTHIFKLPMGLVGNMKADMEASVENEWLCSKIIAEFGVPIAHCDMGSFAGKKALIVER
FDRKLSSDGSWIIRLPQEDFCQATGLSSLLKYQSDGGLSIDDCMKLLASSENAAIDKQHFFKAQIVFYLLAATDGHAKNF
SVTHLPENKYKLTPLYDVLSIHPLIGNKANQIAKQKVKMAMAIRGSKNYYQLQKIQYRHFIQQGKAVGFTEAEVIELIDS
VIRVFDTVIENVSTNLPEGFPTNISNKIFVGMKTQANKLSVHT

Download         Length: 1332 bp

>T43767 NZ_AP027362:c3594326-3592995 [Thalassotalea piscium]
ATGGCAAAACGTAAAGTAAGCGCATTAACTATTTGGATGAACGCAGAGTTTGTTGGTACTTGGCGAATAAAGTCAGGTGT
TGATGAGTTGCAATATGCCGAAGAATGGCTAGAAAACCCGCGAGGTCGCCCCTTATCTTTATCACTACCATTTACTCCAG
GAAACCAACCAATTAAAGGTGATATCGTTTCATTTTACTTTGATAATTTACTGCCTGATAGTAGAGATATACGTGATCGA
TTAGCTAGGCGGTTTAGTACGGCAAGCACCAAGGTATTTGATTTACTCGTTGAGCTTGGTCGTGATTGTGTGGGGGCAAT
TCAATTGCTACCAGAAGGCGAAAAGCCTCAAAATATTAAACAAATTCAGTATAAACCGCTAAATGAACAGCAAGTCGCGG
GAATACTAAATAAAGCTGTTGATACCTATCCGCTAGGCCGTTTAGACGACGATGATGAGCTGAGAATTTCACTTGCTGGC
GCGCAAGAAAAAACCGCGCTACTTTGGCACAATAACCAATGGTGTGAACCTTTAGGAGAAACACCGACAACACATATTTT
TAAACTGCCAATGGGTTTAGTTGGAAATATGAAAGCAGACATGGAAGCCTCTGTTGAAAACGAATGGCTGTGCTCGAAGA
TAATAGCCGAATTTGGTGTTCCTATTGCGCATTGTGATATGGGGTCTTTTGCGGGTAAAAAAGCACTTATTGTTGAGCGT
TTTGATCGTAAATTATCAAGTGATGGCTCATGGATTATTCGATTGCCTCAAGAAGATTTTTGTCAAGCAACTGGTTTGTC
ATCATTGCTTAAATATCAAAGCGATGGGGGGTTGAGTATTGATGATTGTATGAAGCTACTTGCCAGTAGTGAAAATGCAG
CTATTGATAAACAACACTTTTTTAAAGCGCAAATTGTATTTTACTTACTTGCAGCAACCGATGGTCATGCAAAGAATTTT
AGCGTTACTCATTTACCAGAAAATAAATACAAACTAACACCGCTATATGACGTGCTGTCTATTCACCCGCTTATTGGTAA
TAAGGCGAACCAAATTGCTAAACAGAAAGTAAAAATGGCAATGGCCATTCGTGGTAGCAAAAATTACTATCAATTACAAA
AAATACAATATCGGCATTTCATTCAACAGGGCAAAGCAGTAGGATTTACCGAAGCAGAAGTAATTGAGCTTATTGACTCA
GTGATTAGAGTATTTGATACTGTTATTGAAAATGTCAGCACAAATCTCCCTGAAGGCTTTCCAACTAATATATCGAATAA
GATCTTTGTAGGAATGAAAACGCAAGCAAACAAGCTAAGCGTGCACACATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10063.57 Da        Isoelectric Point: 8.4930

>AT43767 WP_184423719.1 NZ_AP027362:c3594595-3594326 [Thalassotalea piscium]
VNYTINTLDQIKPILVGFRKSNGLSQKALAEKLGISQQSYQTLESAPQKVTIERLFKVLSILDIKLQFVEKNKPLESSLS
SNELAQDEW

Download         Length: 270 bp

>AT43767 NZ_AP027362:c3594595-3594326 [Thalassotalea piscium]
GTGAATTACACAATTAATACTCTTGATCAAATTAAACCGATTCTTGTCGGGTTTCGAAAGTCTAATGGACTTTCTCAAAA
AGCGCTGGCTGAAAAACTGGGTATTAGCCAACAAAGCTATCAAACACTTGAAAGCGCACCACAAAAGGTAACGATAGAAC
GTCTGTTTAAAGTGCTTTCTATTTTGGATATAAAGCTACAATTTGTAGAAAAAAATAAACCGCTAGAGAGTAGCTTATCC
AGTAACGAACTCGCGCAGGATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References