Detailed information of TA system TA043725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/HTH_26(antitoxin)
• Location: 2417501..2418609
• Replicon: chromosome
• Accession: NZ_AP027297
• Organism: Enterococcus faecalis strain L6D

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: A0A193AUR0
• Locus tag: QUD71_RS11705
• Protein ID: WP_002378351.1
• Coordinates: 2417501..2418370 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: QUD71_RS11710
• Protein ID: WP_000205227.1
• Coordinates: 2418385..2418609 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUD71_RS11685 (2413772)	2413772..2415091	-	1320	WP_002338419.1	IS1380-like element ISSsu5 family transposase	-
QUD71_RS11690 (2415319)	2415319..2415720	-	402	WP_002401582.1	phosphoribosyltransferase family protein	-
QUD71_RS11695 (2415890)	2415890..2416753	-	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
QUD71_RS11700 (2416786)	2416786..2417520	-	735	WP_000662263.1	class I SAM-dependent methyltransferase	-
QUD71_RS11705 (2417501)	2417501..2418370	-	870	WP_002378351.1	nucleotidyltransferase domain-containing protein	Toxin
QUD71_RS11710 (2418385)	2418385..2418609	-	225	WP_000205227.1	helix-turn-helix transcriptional regulator	Antitoxin
QUD71_RS11715 (2418752)	2418752..2418838	-	87	Protein_2270	site-specific recombinase	-
QUD71_RS11720 (2419027)	2419027..2420328	+	1302	Protein_2271	ISL3 family transposase	-
QUD71_RS11725 (2420567)	2420567..2421247	-	681	WP_010710189.1	IS6-like element IS1216 family transposase	-
QUD71_RS11730 (2421323)	2421323..2421838	-	516	Protein_2273	2-dehydropantoate 2-reductase N-terminal domain-containing protein	-
QUD71_RS11735 (2422015)	2422015..2422905	+	891	WP_002378358.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	erm(B) / ant(6)-Ia	-	2406122..2421247	15125

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32912.50 Da
• Isoelectric Point: 4.7903

>T43725 WP_002378351.1 NZ_AP027297:c2418370-2417501 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T43725 NZ_AP027297:c2418370-2417501 [Enterococcus faecalis]
ATGGTAGGTAATGTTATTCAAATAGTAACAGAGAAATTATCATCTTTGCCTTTTATAGAAGGCATCGTATTAGGGGGCTC
ACGTGCAAGAGGCACCCATACAGAAAATTCTGATATAGATATCGGAATCTATTACAATTCAGACTCATTTGACCTGACAG
CGATTAATCAAATTGCTACAGAATTGGATGATAAAAATAGAAACAACCTTGTTGTGCCTCCCGGAGCGTGGGGTGATTGG
ATTAATGGCGGCGGATGGTTATTTATAAATGGGTATCATGTTGACTTGATTTTACGTGATATAAAACGGGTAGAACAAAT
AATCAAAGATACGGAGCAAGGAATTGTTACTGCCAATTATCAGACCGGGCATCCCCATGGTTATATAAGTGCAATGTATC
GTGGAGAATTAGCGATTAGTAAAATACTATATGCTAAGAACGAAAGCTTATGCGAATTAAAAAAGCAGGCAGAAATTTAC
CCTACTGCTCTAAAGAAAAGCTTGATGAACTTTTTTATATTTGAAGCTGAATTCTCTTTAATGTTTGTAAAAGCAAATGC
GGGGGTAGAGGATAAATATTATATTGCAGGCCATGTTTTTCGTATTATTTCATGCTTAAATCAAGTACTATTTGCATGTA
ATAATGCTTATTGCATTAACGAAAAGAAAGCTATAAAACTGCTTGAAACTTTTGAATATAAACCTGAAAAATATGCCGAA
AGAGTTAATCATATTTTTGAAGTACTCGGTCTTTCTCTTTTTGAATGCTACGACATGACCGAGAAGCTTTATAATGAAGT
GAATGAAATTGTATCGGAGATAAATAACTTTTTAAACGAGGAGAGTTCAGATGAAAGAAAACAAATATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT43725 WP_000205227.1 NZ_AP027297:c2418609-2418385 [Enterococcus faecalis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT43725 NZ_AP027297:c2418609-2418385 [Enterococcus faecalis]
ATGACTACGGCAGAAATGATTAAAGAACTGTGTGAGCAAATGAATATAAGTGTTTCCGAACTTGCTAGACGTATTGGCCA
GACTCCACAGAATTTCAATAAAAAATTACAACGAGAAACAGTAACCTTGGATGAGTTGAAGGCCATTGCTGATGTGCTAG
GTGTCAAGTTTGTGCAGGCATTTATTTTACCAGATGGAGAAGAAATAAAAATATCTAACGAATAA

Structures

Toxin

• AlphaFold DB: A0A193AUR0