Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 2407941..2409078 Replicon chromosome
Accession NZ_AP027297
Organism Enterococcus faecalis strain L6D

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag QUD71_RS11640 Protein ID WP_002401483.1
Coordinates 2407941..2408804 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag QUD71_RS11645 Protein ID WP_000301765.1
Coordinates 2408806..2409078 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD71_RS11610 (2403739) 2403739..2404506 - 768 WP_002357481.1 ribonuclease HII -
QUD71_RS11615 (2404508) 2404508..2405359 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
QUD71_RS11620 (2405635) 2405635..2406066 - 432 Protein_2251 ketopantoate reductase C-terminal domain-containing protein -
QUD71_RS11625 (2406122) 2406122..2406802 - 681 WP_010710189.1 IS6-like element IS1216 family transposase -
QUD71_RS11630 (2406876) 2406876..2407163 - 288 Protein_2253 DnaJ domain-containing protein -
QUD71_RS11635 (2407183) 2407183..2407500 - 318 WP_002333463.1 hypothetical protein -
QUD71_RS11640 (2407941) 2407941..2408804 - 864 WP_002401483.1 zeta toxin family protein Toxin
QUD71_RS11645 (2408806) 2408806..2409078 - 273 WP_000301765.1 antitoxin Antitoxin
QUD71_RS11650 (2409095) 2409095..2409310 - 216 WP_002295735.1 peptide-binding protein -
QUD71_RS11655 (2409409) 2409409..2410305 - 897 WP_002387620.1 ParA family protein -
QUD71_RS11660 (2410408) 2410408..2410668 - 261 Protein_2259 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
QUD71_RS11665 (2410838) 2410838..2411575 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
QUD71_RS11670 (2411700) 2411700..2411783 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
QUD71_RS11675 (2411852) 2411852..2411974 - 123 Protein_2262 peptide-binding protein -
QUD71_RS11680 (2412094) 2412094..2413581 - 1488 WP_229023913.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn erm(B) / ant(6)-Ia - 2406122..2421247 15125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T43724 WP_002401483.1 NZ_AP027297:c2408804-2407941 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

>T43724 NZ_AP027297:c2408804-2407941 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GATTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT43724 WP_000301765.1 NZ_AP027297:c2409078-2408806 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT43724 NZ_AP027297:c2409078-2408806 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References