Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-dinJ/YafQ-DinJ |
| Location | 1645718..1646252 | Replicon | chromosome |
| Accession | NZ_AP027297 | ||
| Organism | Enterococcus faecalis strain L6D | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | R3JX52 |
| Locus tag | QUD71_RS07995 | Protein ID | WP_002360769.1 |
| Coordinates | 1645977..1646252 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | R3H6P0 |
| Locus tag | QUD71_RS07990 | Protein ID | WP_002369771.1 |
| Coordinates | 1645718..1645984 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUD71_RS07955 (1641576) | 1641576..1642361 | + | 786 | WP_048945223.1 | replication-relaxation family protein | - |
| QUD71_RS07960 (1642367) | 1642367..1642855 | + | 489 | WP_048945224.1 | hypothetical protein | - |
| QUD71_RS07965 (1643447) | 1643447..1643713 | + | 267 | WP_002377947.1 | hypothetical protein | - |
| QUD71_RS07970 (1643746) | 1643746..1644246 | + | 501 | WP_002360775.1 | DnaJ domain-containing protein | - |
| QUD71_RS07975 (1644259) | 1644259..1644507 | + | 249 | WP_002360773.1 | DUF3850 domain-containing protein | - |
| QUD71_RS07980 (1644583) | 1644583..1644999 | + | 417 | WP_010710134.1 | single-stranded DNA-binding protein | - |
| QUD71_RS07985 (1645023) | 1645023..1645607 | + | 585 | WP_002377949.1 | thermonuclease family protein | - |
| QUD71_RS07990 (1645718) | 1645718..1645984 | + | 267 | WP_002369771.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| QUD71_RS07995 (1645977) | 1645977..1646252 | + | 276 | WP_002360769.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| QUD71_RS08000 (1646443) | 1646443..1647087 | - | 645 | WP_002377952.1 | IS6 family transposase | - |
| QUD71_RS08005 (1647311) | 1647311..1648285 | + | 975 | WP_002355428.1 | choloylglycine hydrolase | - |
| QUD71_RS08010 (1648954) | 1648954..1649562 | - | 609 | Protein_1552 | IS6 family transposase | - |
| QUD71_RS08015 (1649594) | 1649594..1649779 | - | 186 | WP_002358660.1 | hypothetical protein | - |
| QUD71_RS08020 (1649809) | 1649809..1650138 | + | 330 | WP_002358661.1 | LPXTG cell wall anchor domain-containing protein | - |
| QUD71_RS08025 (1650266) | 1650266..1651204 | + | 939 | WP_002370935.1 | 2-dehydropantoate 2-reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | prgB/asc10 / bsh / cylR2 / cylR1 / cylL / cylS / cylM / cylB / cylA / cylI / bsh | 1600061..1689910 | 89849 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10732.58 Da Isoelectric Point: 9.6918
>T43723 WP_002360769.1 NZ_AP027297:1645977-1646252 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR
Download Length: 276 bp
>T43723 NZ_AP027297:1645977-1646252 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9772.09 Da Isoelectric Point: 4.4791
>AT43723 WP_002369771.1 NZ_AP027297:1645718-1645984 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA
Download Length: 267 bp
>AT43723 NZ_AP027297:1645718-1645984 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2AEA7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M2AED7 |