43716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 976132..977151 Replicon chromosome
Accession NZ_AP027297
Organism Enterococcus faecalis strain L6D

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag QUD71_RS04595 Protein ID WP_137274387.1
Coordinates 976132..976770 (-) Length 213 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QUD71_RS04600 Protein ID WP_002359284.1
Coordinates 976777..977151 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD71_RS04580 (971965) 971965..972972 + 1008 WP_010819692.1 radical SAM protein -
QUD71_RS04585 (973450) 973450..974805 + 1356 WP_010819693.1 PIN-like domain-containing protein -
QUD71_RS04590 (975515) 975515..976090 + 576 WP_002359282.1 restriction endonuclease -
QUD71_RS04595 (976132) 976132..976770 - 639 WP_137274387.1 ImmA/IrrE family metallo-endopeptidase Toxin
QUD71_RS04600 (976777) 976777..977151 - 375 WP_002359284.1 helix-turn-helix domain-containing protein Antitoxin
QUD71_RS04605 (977995) 977995..978177 - 183 WP_129217660.1 hypothetical protein -
QUD71_RS04610 (978344) 978344..978595 + 252 WP_002359287.1 hypothetical protein -
QUD71_RS04615 (978682) 978682..979008 + 327 WP_002359288.1 hypothetical protein -
QUD71_RS04620 (979008) 979008..979415 + 408 WP_159162087.1 DUF961 family protein -
QUD71_RS04625 (979570) 979570..979794 + 225 WP_137274389.1 hypothetical protein -
QUD71_RS04630 (979823) 979823..980014 + 192 WP_137274394.1 hypothetical protein -
QUD71_RS04635 (979996) 979996..980400 + 405 WP_137274390.1 hypothetical protein -
QUD71_RS04640 (980512) 980512..980844 + 333 WP_137274391.1 nucleotidyltransferase domain-containing protein -
QUD71_RS04645 (980834) 980834..981217 + 384 WP_002359294.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 963692..1019029 55337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(86-176)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-61)


Sequences

Toxin        


Download         Length: 213 a.a.        Molecular weight: 25202.20 Da        Isoelectric Point: 9.1676

>T43716 WP_137274387.1 NZ_AP027297:c976770-976132 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDIPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALKYAFSTYDDLEK
MASFFNVNDIVLKIRILDELIYSHNLSYKQANLIYNSYYFQQQTQLKEILFK

Download         Length: 639 bp

>T43716 NZ_AP027297:c976770-976132 [Enterococcus faecalis]
ATGATACTTAATAAGAAAAAATTATATTTCGAAACACAGGCATTTACTGACAAACTTATAAATGAAATTTCAATCAATAT
GTCTAAAAGAAAAGAACTCATCAATTGTTATGATATTGAAGCCTACGTAAAAGAAACCGAAAACATTGATTTTTTTGATT
ATCCATTCAAAAAACAATCTAAAAAATTAATCTGGGGATCAGTAACAAAAATTGGTGATGTAACTATGGTAGCGACTGCC
CAACACTTGAAAATAGAAATTAAAAATTTTACGAAAATGCACGAAATAATTCATCATTATTTTGACTATACGACAGATAT
ACCTAACAATGAAAAATCATTTGATACACTACTTATAAAAAAGGGCTATCTTCCTGAAGATTATCCTAAAGAATTCAGAG
CAAATAAGGGTGCCGGAATGTTACTTATTAATAAAAAAGCCTTAAAGTATGCATTTAGTACTTATGATGATCTTGAAAAA
ATGGCTAGTTTTTTCAACGTAAACGATATAGTTCTCAAGATAAGAATTCTTGACGAATTAATCTATTCCCACAACTTATC
TTATAAACAAGCCAATCTTATTTATAATAGTTACTATTTTCAACAACAAACACAACTTAAAGAGATTTTATTCAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14518.29 Da        Isoelectric Point: 4.8896

>AT43716 WP_002359284.1 NZ_AP027297:c977151-976777 [Enterococcus faecalis]
MKTYEKIKQLRENREITQKEISNALDINVSVYNKIELGIRPLREEELTAIADFFNVSIDYLTGRTDNPTTPSNNQKEAGQ
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE

Download         Length: 375 bp

>AT43716 NZ_AP027297:c977151-976777 [Enterococcus faecalis]
ATGAAAACTTACGAAAAGATAAAACAATTAAGAGAAAATAGAGAAATCACTCAAAAAGAAATTTCAAACGCACTAGACAT
TAATGTTAGTGTATATAATAAAATAGAACTTGGAATACGTCCATTAAGAGAAGAAGAACTTACTGCTATTGCTGATTTTT
TTAATGTTTCAATTGATTATTTAACAGGACGCACTGATAACCCTACAACACCTTCAAATAATCAAAAAGAAGCTGGACAA
AATATTATTTCACATTTCAGATTAAACACTAATGATTTAAGTTCTGATGACATAGAAGAATTAGAAAAAGAATTGATTGA
TTTTCAAGAATTTCTTATAAAACGAGCAAAAGAAAGAAAAAAAAAGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References