Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2144923..2145452 Replicon chromosome
Accession NZ_AP027294
Organism Enterococcus faecium strain K6D

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag QUD90_RS10720 Protein ID WP_002296560.1
Coordinates 2145186..2145452 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag QUD90_RS10715 Protein ID WP_002296559.1
Coordinates 2144923..2145186 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD90_RS10705 (K6D_20550) 2142297..2144120 + 1824 WP_286252741.1 APC family permease -
QUD90_RS10710 (K6D_20560) 2144262..2144447 - 186 WP_002296558.1 transcriptional regulator -
QUD90_RS10715 (K6D_20570) 2144923..2145186 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QUD90_RS10720 (K6D_20580) 2145186..2145452 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
QUD90_RS10725 (K6D_20590) 2145653..2146141 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
QUD90_RS10730 (K6D_20600) 2146682..2147353 - 672 WP_002302663.1 ABC transporter permease -
QUD90_RS10735 (K6D_20610) 2147350..2148267 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
QUD90_RS10740 (K6D_20620) 2148264..2148905 - 642 WP_002293405.1 ABC transporter permease -
QUD90_RS10745 (K6D_20630) 2148909..2150084 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T43694 WP_002296560.1 NZ_AP027294:2145186-2145452 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T43694 NZ_AP027294:2145186-2145452 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT43694 WP_002296559.1 NZ_AP027294:2144923-2145186 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT43694 NZ_AP027294:2144923-2145186 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References