Detailed information of TA system TA043690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2816591..2817228
• Replicon: chromosome
• Accession: NZ_AP027291
• Organism: Mycolicibacterium sp. TUM20985

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: QUE68_RS13905
• Protein ID: WP_284226709.1
• Coordinates: 2816591..2816986 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: QUE68_RS13910
• Protein ID: WP_284226710.1
• Coordinates: 2816983..2817228 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE68_RS13875	2812443..2812799	+	357	WP_284226703.1	hypothetical protein	-
QUE68_RS13880 (TUM20985_27600)	2813063..2813350	-	288	WP_284226704.1	WXG100 family type VII secretion target	-
QUE68_RS13885 (TUM20985_27610)	2813350..2813652	-	303	WP_284226705.1	WXG100 family type VII secretion target	-
QUE68_RS13890 (TUM20985_27620)	2813845..2814489	+	645	WP_284226706.1	class I SAM-dependent methyltransferase	-
QUE68_RS13895 (TUM20985_27630)	2814505..2815314	-	810	WP_284226707.1	hypothetical protein	-
QUE68_RS13900 (TUM20985_27640)	2815439..2816401	+	963	WP_284226708.1	hypothetical protein	-
QUE68_RS13905 (TUM20985_27650)	2816591..2816986	-	396	WP_284226709.1	type II toxin-antitoxin system VapC family toxin	Toxin
QUE68_RS13910 (TUM20985_27660)	2816983..2817228	-	246	WP_284226710.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
QUE68_RS13915 (TUM20985_27670)	2817317..2818972	-	1656	WP_284226711.1	NERD domain-containing protein	-
QUE68_RS13920 (TUM20985_27680)	2819063..2819809	-	747	Protein_2747	alpha/beta hydrolase	-
QUE68_RS13925 (TUM20985_27690)	2820042..2820518	-	477	WP_284236049.1	hypothetical protein	-
QUE68_RS13930 (TUM20985_27700)	2820578..2820949	-	372	WP_284236048.1	DoxX family protein	-
QUE68_RS13935 (TUM20985_27710)	2820981..2821370	+	390	WP_284236047.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2790145..2898333	108188

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14220.00 Da
• Isoelectric Point: 4.4008

>T43690 WP_284226709.1 NZ_AP027291:c2816986-2816591 [Mycolicibacterium sp. TUM20985]
MIVDSSAIIAILRDEDDAAVYARAITTADVRRLSVASYVECGCVVDSQRDPVVSRGLDELIETAEISMEPVTERQARLAR
QAYRDFGKGSGHPAGLNFGDCLSYALAIDMREPLLWKGNDFGHTGIESAIS

Nucleotide

• Length: 396 bp

>T43690 NZ_AP027291:c2816986-2816591 [Mycolicibacterium sp. TUM20985]
TTGATCGTGGATTCGTCGGCGATCATCGCGATCCTGAGAGACGAGGACGACGCAGCGGTGTACGCCCGAGCGATCACGAC
TGCCGACGTACGACGACTATCCGTGGCCAGCTACGTCGAATGTGGTTGTGTGGTCGACTCGCAAAGAGATCCCGTCGTCA
GCAGGGGATTGGATGAATTAATCGAGACGGCGGAGATCTCGATGGAACCGGTGACTGAACGCCAGGCACGCCTGGCGCGT
CAGGCGTACCGCGACTTCGGAAAGGGCAGCGGCCACCCCGCCGGACTGAACTTCGGCGACTGCCTGTCATACGCCCTGGC
CATCGACATGCGCGAACCGCTGCTGTGGAAGGGCAACGACTTTGGCCACACCGGGATCGAATCCGCGATTAGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8780.97 Da
• Isoelectric Point: 4.7124

>AT43690 WP_284226710.1 NZ_AP027291:c2817228-2816983 [Mycolicibacterium sp. TUM20985]
MALNIKDPSVHEAVKQLAALTGESQSQAVAMAVNERLARLQQDDLAVRLLGIGHKTAQRMNSATEMLDHAELLYDDEGLP
A

Nucleotide

• Length: 246 bp

>AT43690 NZ_AP027291:c2817228-2816983 [Mycolicibacterium sp. TUM20985]
ATGGCGTTGAACATAAAGGATCCGTCGGTCCACGAAGCGGTCAAGCAGCTCGCCGCGCTGACGGGCGAGTCGCAGTCCCA
GGCGGTGGCGATGGCCGTCAACGAACGCCTGGCACGACTGCAGCAGGACGACCTCGCCGTCCGTCTCCTCGGCATTGGCC
ATAAGACAGCGCAGCGAATGAATTCAGCGACTGAGATGCTCGACCATGCCGAGCTGCTGTACGACGACGAAGGCCTACCA
GCTTGA