43689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2574259..2575234 Replicon chromosome
Accession NZ_AP027291
Organism Mycolicibacterium sp. TUM20985

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag QUE68_RS12665 Protein ID WP_286275683.1
Coordinates 2574656..2575234 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag QUE68_RS12660 Protein ID WP_286275682.1
Coordinates 2574259..2574648 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE68_RS12645 (TUM20985_25130) 2570006..2571226 + 1221 WP_286275679.1 SfnB family sulfur acquisition oxidoreductase -
QUE68_RS12650 (TUM20985_25140) 2571227..2573059 - 1833 WP_286275680.1 fatty acyl-AMP ligase -
QUE68_RS12655 (TUM20985_25150) 2573124..2574143 - 1020 WP_286275681.1 NADP-dependent oxidoreductase -
QUE68_RS12660 (TUM20985_25160) 2574259..2574648 + 390 WP_286275682.1 hypothetical protein Antitoxin
QUE68_RS12665 (TUM20985_25170) 2574656..2575234 + 579 WP_286275683.1 zeta toxin family protein Toxin
QUE68_RS12670 (TUM20985_25180) 2575238..2575849 - 612 WP_286275684.1 NlpC/P60 family peptidoglycan-binding protein RipD -
QUE68_RS12675 (TUM20985_25190) 2576036..2576713 + 678 WP_286275685.1 thiaminase II -
QUE68_RS12680 (TUM20985_25200) 2576824..2577759 + 936 WP_286275686.1 R2-like ligand-binding oxidase -
QUE68_RS12685 (TUM20985_25210) 2577772..2578266 - 495 WP_284234149.1 thiol peroxidase -
QUE68_RS12690 (TUM20985_25220) 2578304..2579320 - 1017 WP_284234151.1 NAD(P)/FAD-dependent oxidoreductase -
QUE68_RS12695 (TUM20985_25230) 2579317..2579826 - 510 WP_284234153.1 isoprenylcysteine carboxyl methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-149)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 20831.66 Da        Isoelectric Point: 7.5911

>T43689 WP_286275683.1 NZ_AP027291:2574656-2575234 [Mycolicibacterium sp. TUM20985]
VNRLDLVVGPNGAGKSTFVELTLAPLLPRSVFVNADEIARQRWPDEPASHAYDAARIAADTRSALIDSHVSFIAETVFSH
PSKLELIATAHTAGYTIALHALMIPEDLAVERVAYRVQAGGHAVPPDKIRERYRRLWSHVAEAVARCDTAVVYDGSGHRG
PRIVAQLSGGNVIGAPSWPAWAPHELAKRWPA

Download         Length: 579 bp

>T43689 NZ_AP027291:2574656-2575234 [Mycolicibacterium sp. TUM20985]
GTGAACCGTCTCGACCTGGTGGTCGGTCCGAACGGCGCGGGCAAGTCGACGTTCGTGGAGTTGACCCTCGCGCCGCTCCT
GCCGAGAAGTGTCTTCGTCAACGCCGACGAGATCGCCAGGCAACGCTGGCCCGACGAGCCCGCGTCACACGCCTATGACG
CCGCCAGGATCGCGGCCGACACCCGGTCGGCGCTCATCGACTCGCACGTGTCGTTCATCGCCGAGACCGTCTTCTCGCAC
CCATCGAAACTCGAGCTCATCGCGACTGCCCACACCGCGGGCTACACGATCGCGTTGCACGCGTTGATGATTCCCGAGGA
CCTCGCGGTCGAGCGGGTCGCCTACCGGGTGCAGGCGGGTGGGCACGCCGTGCCGCCGGACAAGATCCGCGAACGGTACC
GCCGGCTGTGGTCGCACGTCGCCGAGGCCGTCGCCCGCTGCGACACCGCCGTCGTCTACGACGGCAGCGGCCACCGAGGC
CCGCGCATCGTCGCCCAGCTCAGCGGCGGCAACGTGATCGGTGCGCCGTCGTGGCCCGCGTGGGCACCGCACGAACTAGC
GAAGCGCTGGCCCGCCTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13647.09 Da        Isoelectric Point: 4.7453

>AT43689 WP_286275682.1 NZ_AP027291:2574259-2574648 [Mycolicibacterium sp. TUM20985]
MSEVADRVTRFAADLVDSAEAEGARQSRSTKQQLDHWVRVGRAVSSQQTAARRRVEAALAGQLPLAELTVEEGVVFNAEI
AAGIDESLSRTDYGRVLAGRGITTVALDGDGNIVEHRPDGTSTVLTGAT

Download         Length: 390 bp

>AT43689 NZ_AP027291:2574259-2574648 [Mycolicibacterium sp. TUM20985]
ATGTCGGAAGTCGCCGATCGAGTCACCCGTTTCGCTGCCGACCTCGTCGACAGCGCCGAAGCCGAGGGTGCCCGCCAGAG
TAGGTCGACCAAACAGCAGCTGGACCACTGGGTGCGGGTCGGACGCGCAGTGTCGAGCCAGCAGACCGCCGCCCGTCGGC
GGGTCGAGGCCGCACTGGCGGGTCAGCTTCCGTTGGCAGAGCTGACGGTCGAGGAGGGCGTGGTGTTCAACGCGGAGATC
GCCGCCGGCATCGACGAGAGCCTGTCCCGCACCGACTACGGCCGGGTTCTCGCCGGCCGCGGGATCACGACCGTGGCCCT
CGACGGCGACGGCAACATCGTCGAACACCGCCCGGATGGGACCTCGACCGTGTTGACCGGCGCCACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References