Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2548398..2548933 Replicon chromosome
Accession NZ_AP027291
Organism Mycolicibacterium sp. TUM20985

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QUE68_RS12485 Protein ID WP_284226375.1
Coordinates 2548398..2548730 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QUE68_RS12490 Protein ID WP_284226377.1
Coordinates 2548727..2548933 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE68_RS12460 (TUM20985_24770) 2543410..2544885 + 1476 WP_286275812.1 aspartate ammonia-lyase -
QUE68_RS12465 (TUM20985_24780) 2544922..2545350 - 429 WP_284226370.1 VOC family protein -
QUE68_RS12470 (TUM20985_24790) 2545613..2546326 - 714 WP_286275665.1 transposase -
QUE68_RS12475 (TUM20985_24810) 2546628..2546984 - 357 Protein_2458 ATP-binding protein -
QUE68_RS12480 (TUM20985_24820) 2546981..2547754 - 774 WP_286275666.1 hypothetical protein -
QUE68_RS12485 (TUM20985_24830) 2548398..2548730 - 333 WP_284226375.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QUE68_RS12490 (TUM20985_24840) 2548727..2548933 - 207 WP_284226377.1 DUF3018 family protein Antitoxin
QUE68_RS12495 (TUM20985_24850) 2549293..2549541 - 249 WP_284234093.1 DUF3297 family protein -
QUE68_RS12500 (TUM20985_24860) 2550014..2550223 + 210 WP_286275667.1 hypothetical protein -
QUE68_RS12505 2550256..2550411 - 156 Protein_2464 aldo/keto reductase -
QUE68_RS12510 (TUM20985_24880) 2550532..2551341 + 810 WP_284226383.1 LLM class F420-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11966.79 Da        Isoelectric Point: 7.0139

>T43688 WP_284226375.1 NZ_AP027291:c2548730-2548398 [Mycolicibacterium sp. TUM20985]
VNRGEIWTVAGGVYATKPRPAMIVQDDLFDATSSVTVAPMTSTLLDAPLIRIRIAGGDGRLSGLDRDSDVMIDKLTTVRR
SNVHDRVGRLTAEQLVEVERAMMAFLGLAR

Download         Length: 333 bp

>T43688 NZ_AP027291:c2548730-2548398 [Mycolicibacterium sp. TUM20985]
GTGAATCGAGGGGAGATCTGGACCGTAGCGGGGGGTGTCTACGCGACGAAACCGCGTCCGGCAATGATCGTTCAGGACGA
TCTTTTCGACGCCACGAGTTCGGTGACGGTCGCGCCGATGACCAGCACGCTGTTGGATGCGCCGCTGATTCGTATTCGGA
TAGCCGGTGGAGACGGCCGGCTATCCGGACTTGATCGCGATAGTGACGTGATGATCGACAAGCTCACCACCGTCAGAAGG
TCGAACGTCCACGACCGGGTCGGTCGGCTGACCGCAGAGCAACTCGTTGAGGTCGAGCGGGCAATGATGGCATTCCTCGG
CCTTGCCCGATGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 8004.88 Da        Isoelectric Point: 4.8537

>AT43688 WP_284226377.1 NZ_AP027291:c2548933-2548727 [Mycolicibacterium sp. TUM20985]
MAVRERVGEYRRRMRERGLRPVQVWVPDVRTEGFAAEARRQASLVARADERSDDQDFIEAVSTPWDEE

Download         Length: 207 bp

>AT43688 NZ_AP027291:c2548933-2548727 [Mycolicibacterium sp. TUM20985]
ATGGCGGTGAGGGAGAGGGTCGGCGAGTACCGACGGCGTATGCGCGAGCGGGGGCTGCGGCCAGTGCAGGTCTGGGTGCC
TGACGTGCGCACTGAGGGTTTCGCCGCCGAGGCGCGTCGCCAGGCCTCATTGGTCGCACGAGCGGACGAACGCAGCGATG
ACCAGGACTTCATCGAGGCCGTCTCGACGCCATGGGACGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References