Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4732236..4732752 Replicon chromosome
Accession NZ_AP027263
Organism Klebsiella pneumoniae strain TA8711

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QUE17_RS23365 Protein ID WP_002886902.1
Coordinates 4732236..4732520 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QUE17_RS23370 Protein ID WP_002886901.1
Coordinates 4732510..4732752 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE17_RS23340 (KPTA8711_45160) 4727720..4728028 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
QUE17_RS23345 4728113..4728286 + 174 WP_002886906.1 hypothetical protein -
QUE17_RS23350 (KPTA8711_45170) 4728289..4729032 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QUE17_RS23355 (KPTA8711_45180) 4729389..4731527 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
QUE17_RS23360 (KPTA8711_45190) 4731768..4732232 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QUE17_RS23365 (KPTA8711_45200) 4732236..4732520 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUE17_RS23370 (KPTA8711_45210) 4732510..4732752 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QUE17_RS23375 (KPTA8711_45220) 4732830..4734740 - 1911 WP_004152270.1 PRD domain-containing protein -
QUE17_RS23380 (KPTA8711_45230) 4734763..4735917 - 1155 WP_002886900.1 lactonase family protein -
QUE17_RS23385 (KPTA8711_45240) 4735983..4736723 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T43682 WP_002886902.1 NZ_AP027263:c4732520-4732236 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T43682 NZ_AP027263:c4732520-4732236 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT43682 WP_002886901.1 NZ_AP027263:c4732752-4732510 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT43682 NZ_AP027263:c4732752-4732510 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References