Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4001603..4002222 Replicon chromosome
Accession NZ_AP027263
Organism Klebsiella pneumoniae strain TA8711

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QUE17_RS19830 Protein ID WP_002892050.1
Coordinates 4002004..4002222 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag QUE17_RS19825 Protein ID WP_002892066.1
Coordinates 4001603..4001977 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE17_RS19815 (KPTA8711_38310) 3996755..3997948 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QUE17_RS19820 (KPTA8711_38320) 3997971..4001117 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
QUE17_RS19825 (KPTA8711_38330) 4001603..4001977 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
QUE17_RS19830 (KPTA8711_38340) 4002004..4002222 + 219 WP_002892050.1 HHA domain-containing protein Toxin
QUE17_RS19835 (KPTA8711_38350) 4002381..4002947 + 567 WP_002892030.1 maltose O-acetyltransferase -
QUE17_RS19840 4002919..4003059 - 141 WP_004147370.1 hypothetical protein -
QUE17_RS19845 (KPTA8711_38360) 4003080..4003550 + 471 WP_002892026.1 YlaC family protein -
QUE17_RS19850 (KPTA8711_38370) 4003525..4004976 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
QUE17_RS19855 (KPTA8711_38380) 4005077..4005775 + 699 WP_002892021.1 GNAT family protein -
QUE17_RS19860 (KPTA8711_38390) 4005772..4005912 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
QUE17_RS19865 (KPTA8711_38400) 4005912..4006175 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T43680 WP_002892050.1 NZ_AP027263:4002004-4002222 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T43680 NZ_AP027263:4002004-4002222 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT43680 WP_002892066.1 NZ_AP027263:4001603-4001977 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT43680 NZ_AP027263:4001603-4001977 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References