Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 940952..941757 Replicon chromosome
Accession NZ_AP027263
Organism Klebsiella pneumoniae strain TA8711

Toxin (Protein)


Gene name yeeV Uniprot ID A0A443UJW7
Locus tag QUE17_RS04760 Protein ID WP_065523303.1
Coordinates 941368..941757 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8B4U7X6
Locus tag QUE17_RS04755 Protein ID WP_065523304.1
Coordinates 940952..941311 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE17_RS04725 (KPTA8711_09290) 936844..937932 + 1089 WP_065523308.1 patatin-like phospholipase family protein -
QUE17_RS04730 938068..938226 - 159 Protein_930 transposase -
QUE17_RS04735 (KPTA8711_09300) 938898..939719 + 822 WP_065523307.1 DUF932 domain-containing protein -
QUE17_RS04740 (KPTA8711_09310) 939752..940201 + 450 WP_065523306.1 antirestriction protein -
QUE17_RS04745 (KPTA8711_09320) 940213..940692 + 480 WP_065523305.1 DNA repair protein RadC -
QUE17_RS04750 (KPTA8711_09330) 940706..940927 + 222 WP_004192297.1 DUF987 domain-containing protein -
QUE17_RS04755 (KPTA8711_09340) 940952..941311 + 360 WP_065523304.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QUE17_RS04760 (KPTA8711_09350) 941368..941757 + 390 WP_065523303.1 TA system toxin CbtA family protein Toxin
QUE17_RS04765 (KPTA8711_09360) 941830..942669 + 840 WP_065523302.1 DUF4942 domain-containing protein -
QUE17_RS04770 (KPTA8711_09370) 943010..944398 - 1389 WP_004151784.1 MFS transporter -
QUE17_RS04775 (KPTA8711_09380) 944528..945457 + 930 WP_002916293.1 LysR family transcriptional regulator -
QUE17_RS04780 (KPTA8711_09390) 945821..946624 - 804 WP_002916291.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14411.53 Da        Isoelectric Point: 9.8627

>T43670 WP_065523303.1 NZ_AP027263:941368-941757 [Klebsiella pneumoniae]
MQTKSSPLMRAASSRPSPVYIWQTLLTSLLAQHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR

Download         Length: 390 bp

>T43670 NZ_AP027263:941368-941757 [Klebsiella pneumoniae]
ATGCAAACCAAATCATCCCCCCTCATGCGGGCGGCATCGTCACGTCCGTCTCCCGTGTATATCTGGCAGACCCTGCTGAC
CAGCCTGCTGGCACAACACTATGGACTCACGCTTAGCGATACGCCGTTCAGTGATGAACAGGTCATTCAGCAACATATTG
ATGCCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTC
AGCATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCGATTACCAGAGGGCAACATCCGCAGGTCAGCGCTCCAGGCAAGCGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13377.23 Da        Isoelectric Point: 7.0371

>AT43670 WP_065523304.1 NZ_AP027263:940952-941311 [Klebsiella pneumoniae]
MSKKTTITTHDISEPWWGLRRSTSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQSFPVLMKQLELMLTSGELN
PRHQHGIILYAKGLTCEADTLGSHGYVYIAIYPTPVATA

Download         Length: 360 bp

>AT43670 NZ_AP027263:940952-941311 [Klebsiella pneumoniae]
TTGTCGAAGAAAACCACAATAACAACGCATGATATCAGCGAACCCTGGTGGGGACTCAGACGCAGTACCTCCCCGTGTTT
TGGTGCCCGTCTGGTCCAGGAGGGGAACCGCCTGCATTACCTGGCTGACCGCGCGAACTTTGATGGTCAGTTCTGTGATG
CGGATTTGCGCCATCTTGACCAGTCTTTCCCGGTATTAATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAAC
CCCCGTCATCAGCATGGCATCATACTGTATGCAAAAGGTCTGACCTGCGAGGCGGATACGCTCGGTTCGCATGGCTATGT
TTATATCGCGATTTATCCCACTCCCGTCGCCACGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A443UJW7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4U7X6

References