Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 900154..900811 Replicon chromosome
Accession NZ_AP027263
Organism Klebsiella pneumoniae strain TA8711

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QUE17_RS04560 Protein ID WP_002916310.1
Coordinates 900401..900811 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QUE17_RS04555 Protein ID WP_002916312.1
Coordinates 900154..900420 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE17_RS04530 (KPTA8711_08900) 895310..896743 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QUE17_RS04535 (KPTA8711_08910) 896862..897590 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QUE17_RS04540 (KPTA8711_08920) 897640..897951 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
QUE17_RS04545 (KPTA8711_08930) 898115..898774 + 660 WP_002916317.1 hemolysin III family protein -
QUE17_RS04550 (KPTA8711_08940) 898925..899908 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QUE17_RS04555 (KPTA8711_08950) 900154..900420 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QUE17_RS04560 (KPTA8711_08960) 900401..900811 + 411 WP_002916310.1 protein YgfX Toxin
QUE17_RS04565 (KPTA8711_08970) 900818..901339 - 522 WP_002916308.1 flavodoxin FldB -
QUE17_RS04570 (KPTA8711_08980) 901440..902336 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QUE17_RS04575 (KPTA8711_08990) 902359..903072 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QUE17_RS04580 (KPTA8711_09000) 903078..904811 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T43669 WP_002916310.1 NZ_AP027263:900401-900811 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T43669 NZ_AP027263:900401-900811 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT43669 WP_002916312.1 NZ_AP027263:900154-900420 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT43669 NZ_AP027263:900154-900420 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References