Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4535708..4536752 Replicon chromosome
Accession NZ_AP027258
Organism Escherichia coli strain JNE151685

Toxin (Protein)


Gene name panT Uniprot ID A0A3W2VTW9
Locus tag QUE29_RS22240 Protein ID WP_000089360.1
Coordinates 4536204..4536752 (+) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag QUE29_RS22235 Protein ID WP_000287252.1
Coordinates 4535708..4536181 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE29_RS22200 (4530739) 4530739..4531347 + 609 WP_000646078.1 transcriptional repressor LexA -
QUE29_RS22205 (4531420) 4531420..4532745 + 1326 WP_001295692.1 MATE family efflux transporter DinF -
QUE29_RS22210 (4532861) 4532861..4533070 + 210 WP_001030593.1 CsbD family protein -
QUE29_RS22215 (4533112) 4533112..4533627 - 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
QUE29_RS22220 (4533945) 4533945..4534199 + 255 Protein_4327 hypothetical protein -
QUE29_RS22225 (4534223) 4534223..4534935 + 713 Protein_4328 DUF2713 family protein -
QUE29_RS22230 (4535298) 4535298..4535399 + 102 Protein_4329 tRNA-dihydrouridine synthase -
QUE29_RS22235 (4535708) 4535708..4536181 + 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
QUE29_RS22240 (4536204) 4536204..4536752 + 549 WP_000089360.1 hypothetical protein Toxin
QUE29_RS22245 (4536786) 4536786..4537058 - 273 WP_001093911.1 pyocin activator PrtN family protein -
QUE29_RS22250 (4537095) 4537095..4537667 - 573 WP_001061343.1 3'-5' exonuclease -
QUE29_RS22255 (4537667) 4537667..4538476 - 810 WP_000206746.1 hypothetical protein -
QUE29_RS22260 (4538476) 4538476..4538838 - 363 WP_001242725.1 hypothetical protein -
QUE29_RS22265 (4538829) 4538829..4539365 - 537 WP_000008232.1 5'-deoxynucleotidase -
QUE29_RS22270 (4539493) 4539493..4540317 - 825 WP_000081316.1 DUF2303 family protein -
QUE29_RS22275 (4540383) 4540383..4540745 - 363 WP_000135680.1 protein YfdP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stx2A / stx2B 4530739..4585327 54588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20028.54 Da        Isoelectric Point: 4.6708

>T43658 WP_000089360.1 NZ_AP027258:4536204-4536752 [Escherichia coli]
MSRNSDIYKLIGAAAGVENGRSEASLNYTDSQEQVFKSAFESSNHESDDGSSSENKAILEEEEFGSNTGALHEFMQQHRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVCFMSWWCLFVAVMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Download         Length: 549 bp

>T43658 NZ_AP027258:4536204-4536752 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGTCGTCTAATCATGAGAGCGATGATGGTTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGCTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTGGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT43658 WP_000287252.1 NZ_AP027258:4535708-4536181 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT43658 NZ_AP027258:4535708-4536181 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W2VTW9

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References