43635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4935839..4937174 Replicon chromosome
Accession NZ_AP027256
Organism Escherichia coli strain JNE141411

Toxin (Protein)


Gene name sanaT Uniprot ID A0A3L9IFW6
Locus tag QUD91_RS24260 Protein ID WP_038977127.1
Coordinates 4936227..4937174 (+) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A3L2P891
Locus tag QUD91_RS24255 Protein ID WP_038977126.1
Coordinates 4935839..4936234 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD91_RS24225 (4931603) 4931603..4932400 + 798 WP_286335445.1 hypothetical protein -
QUD91_RS24230 (4932793) 4932793..4933611 + 819 WP_053264532.1 DUF932 domain-containing protein -
QUD91_RS24235 (4933641) 4933641..4934114 + 474 WP_001296921.1 DNA repair protein RadC -
QUD91_RS24240 (4934114) 4934114..4934449 + 336 WP_053264533.1 type IV toxin-antitoxin system YeeU family antitoxin -
QUD91_RS24245 (4934480) 4934480..4934821 + 342 WP_053264534.1 TA system toxin CbtA family protein -
QUD91_RS24250 (4934936) 4934936..4935769 + 834 WP_038977125.1 DUF4942 domain-containing protein -
QUD91_RS24255 (4935839) 4935839..4936234 + 396 WP_038977126.1 DUF6088 family protein Antitoxin
QUD91_RS24260 (4936227) 4936227..4937174 + 948 WP_038977127.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QUD91_RS24265 (4937567) 4937567..4938832 + 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
QUD91_RS24270 (4939033) 4939033..4940502 - 1470 WP_001022619.1 serine/threonine-protein kinase -
QUD91_RS24275 (4940499) 4940499..4941041 - 543 WP_001115385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB / fimE / fimA / fimI / fimC 4919716..4967460 47744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35634.77 Da        Isoelectric Point: 4.8847

>T43635 WP_038977127.1 NZ_AP027256:4936227-4937174 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSSVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSQLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYEMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

>T43635 NZ_AP027256:4936227-4937174 [Escherichia coli]
ATGGATGATTTAACCACTCTTTTTTCTGAAGTGGCTGACGCGCTTGGTATTGAGTCTGTCGCAATTGTGGAAAAAGATCA
CTATATCGTTGAGCTTTTGCAATTGCTTAAACCTCTGGTGTTCGATACTCATCAATTGGTGTTTGCCGGAGGAACCGCTC
TGGCAAAATCAAGTGTCGCACTTAATCGCATGTCGGAAGATGTGGATATCAAACTGGTGCCTAAGGATGCATTTCAGGCA
CTTTCCCGCACTCAGCGAAAAAATACCCGTAAAGAAATTGTTCAGGCAGTTTCCAGTGCAATAGCTTCATCGGGTGTGTT
CAATTTTGATGATGATTACCCAAAAGTGACGCGGGATGAATATCGTTATAATGACATACCTGTTCGTTATCCACAGCGAG
TGGTGCAGGCACCTTGTTTGCGTCCTTTTATCCGGCTGGAATTGATGGAAGCGAAGTTACTGGAGCCTTCTGAATTACGG
GATATTCATTCACTGGTAACAGGGATCACGGGAAAAGCGGCTATTGTTTCAGCGTTTCCATGCGCAACTATCATTAGCAC
ACAGGCAGAAAAGCTGGTGGCGATGTTACGTCGTACTGCGGCAGTTGTGCGAGATGTTGAGCGATTTGATGATGCATCGC
TGGTACGTCATATCTACGATACAAACTGTATTGTTGAGACGAGTCATGTTGATATGAGTCAGCTCGTTGATTTTGTTCAA
CAAACTATTGAGCAGGACATTCAGCGTTACGGCAACCAGTACCCGCAGTTTTGCGCGTCTCCAGTTGATGAGCTAAAAAT
GGGACTGGATGAGTTGGCGAACAATCCTCTCTACGAGATGCGCTATCAGCAGTTTGTTTCGCCAATGGTGTATGGAGAGC
GAAAGATCACATGGGATGAGGCTTACTCCAGGTTTAGGAGCTTAGCGCTAGCCATCCTGAATGCTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14586.86 Da        Isoelectric Point: 11.5650

>AT43635 WP_038977126.1 NZ_AP027256:4935839-4936234 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVHYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp

>AT43635 NZ_AP027256:4935839-4936234 [Escherichia coli]
ATGACGATAAAAGCACGCATTCAGTCACGACTGAAACGTTCTAAACGTTACGTATTCACTCGTGACGACTTTAAAGATAT
TGCAGGCTACGATCAGGTTGGTCGGGTATTGCGCGATCTTGTCAGGGAAGGGCAACTGTTGAAGGTTGGTTATGGCGTGT
ATACCAAAGCACGGCGGAACGGTATTACAGGCAAGGTAATGCCAGCGGCTCCCGGAGGCTCTTCAGCGGTGATTGTCGAA
ACGCTGGAACGCCTGAAAGTACACTATCGTTTTGCTGGCGCAACGCAGGCATACAATAGCGGTACTTCTACGCAGATCCC
AGCTTCACCCGAGATAAAAACCCCCCGGCGTTTTAAACGCGTATTATCTGTAGGGAACAGCAGATTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9IFW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3L2P891

References