43629

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3939219..3939850 Replicon chromosome
Accession NZ_AP027256
Organism Escherichia coli strain JNE141411

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag QUD91_RS19500 Protein ID WP_001259388.1
Coordinates 3939575..3939850 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QUD91_RS19495 Protein ID WP_000593555.1
Coordinates 3939219..3939578 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD91_RS19470 (3935351) 3935351..3936295 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
QUD91_RS19475 (3936292) 3936292..3937125 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QUD91_RS19480 (3937125) 3937125..3937889 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QUD91_RS19485 (3937886) 3937886..3938692 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QUD91_RS19490 (3938698) 3938698..3939099 + 402 WP_001190064.1 nickel-responsive transcriptional regulator NikR -
QUD91_RS19495 (3939219) 3939219..3939578 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QUD91_RS19500 (3939575) 3939575..3939850 - 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
QUD91_RS19505 (3939923) 3939923..3941047 - 1125 WP_001615305.1 ABC transporter permease -
QUD91_RS19510 (3941047) 3941047..3943782 - 2736 WP_286335328.1 ribosome-associated ATPase/putative transporter RbbA -
QUD91_RS19515 (3943779) 3943779..3944846 - 1068 WP_000361482.1 HlyD family efflux transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T43629 WP_001259388.1 NZ_AP027256:c3939850-3939575 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T43629 NZ_AP027256:c3939850-3939575 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT43629 WP_000593555.1 NZ_AP027256:c3939578-3939219 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT43629 NZ_AP027256:c3939578-3939219 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References