43626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3266795..3267449 Replicon chromosome
Accession NZ_AP027256
Organism Escherichia coli strain JNE141411

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag QUD91_RS16110 Protein ID WP_000244772.1
Coordinates 3266795..3267202 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QUD91_RS16115 Protein ID WP_000354046.1
Coordinates 3267183..3267449 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD91_RS16090 (3262752) 3262752..3264485 - 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -
QUD91_RS16095 (3264491) 3264491..3265201 - 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QUD91_RS16100 (3265226) 3265226..3266122 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QUD91_RS16105 (3266234) 3266234..3266755 + 522 WP_001055874.1 flavodoxin FldB -
QUD91_RS16110 (3266795) 3266795..3267202 - 408 WP_000244772.1 protein YgfX Toxin
QUD91_RS16115 (3267183) 3267183..3267449 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QUD91_RS16120 (3267692) 3267692..3268672 + 981 WP_000886095.1 tRNA-modifying protein YgfZ -
QUD91_RS16125 (3268868) 3268868..3269527 - 660 WP_000250274.1 hemolysin III family protein -
QUD91_RS16130 (3269691) 3269691..3270002 - 312 WP_286335246.1 N(4)-acetylcytidine aminohydrolase -
QUD91_RS16135 (3270047) 3270047..3271480 + 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
QUD91_RS16140 (3271537) 3271537..3272280 - 744 WP_000951941.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T43626 WP_000244772.1 NZ_AP027256:c3267202-3266795 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T43626 NZ_AP027256:c3267202-3266795 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT43626 WP_000354046.1 NZ_AP027256:c3267449-3267183 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT43626 NZ_AP027256:c3267449-3267183 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References