43624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2798265..2798890 Replicon chromosome
Accession NZ_AP027256
Organism Escherichia coli strain JNE141411

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag QUD91_RS13765 Protein ID WP_000911329.1
Coordinates 2798265..2798663 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QUD91_RS13770 Protein ID WP_000450524.1
Coordinates 2798663..2798890 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD91_RS13745 (2794143) 2794143..2794343 + 201 WP_000383836.1 YpfN family protein -
QUD91_RS13750 (2794453) 2794453..2795151 - 699 WP_286335187.1 esterase -
QUD91_RS13755 (2795225) 2795225..2797240 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
QUD91_RS13760 (2797255) 2797255..2798118 - 864 WP_001267498.1 neutral zinc metallopeptidase -
QUD91_RS13765 (2798265) 2798265..2798663 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
QUD91_RS13770 (2798663) 2798663..2798890 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QUD91_RS13775 (2799045) 2799045..2799758 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QUD91_RS13780 (2799971) 2799971..2801005 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QUD91_RS13785 (2801022) 2801022..2801900 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QUD91_RS13790 (2802046) 2802046..2802618 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QUD91_RS13795 (2802618) 2802618..2803088 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T43624 WP_000911329.1 NZ_AP027256:c2798663-2798265 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T43624 NZ_AP027256:c2798663-2798265 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT43624 WP_000450524.1 NZ_AP027256:c2798890-2798663 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT43624 NZ_AP027256:c2798890-2798663 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References