Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 502403..503021 Replicon chromosome
Accession NZ_AP027256
Organism Escherichia coli strain JNE141411

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QUD91_RS02325 Protein ID WP_001291435.1
Coordinates 502403..502621 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag QUD91_RS02330 Protein ID WP_000344794.1
Coordinates 502647..503021 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD91_RS02290 (497693) 497693..498265 + 573 WP_000779831.1 YbaY family lipoprotein -
QUD91_RS02295 (498296) 498296..498607 - 312 WP_000409911.1 MGMT family protein -
QUD91_RS02305 (498986) 498986..499339 + 354 WP_000878140.1 DUF1428 domain-containing protein -
QUD91_RS02310 (499381) 499381..500931 - 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QUD91_RS02315 (501095) 501095..501565 - 471 WP_000136192.1 YlaC family protein -
QUD91_RS02320 (501681) 501681..502232 - 552 WP_000102564.1 maltose O-acetyltransferase -
QUD91_RS02325 (502403) 502403..502621 - 219 WP_001291435.1 HHA domain-containing protein Toxin
QUD91_RS02330 (502647) 502647..503021 - 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
QUD91_RS02335 (503567) 503567..506716 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QUD91_RS02340 (506739) 506739..507932 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T43612 WP_001291435.1 NZ_AP027256:c502621-502403 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T43612 NZ_AP027256:c502621-502403 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT43612 WP_000344794.1 NZ_AP027256:c503021-502647 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT43612 NZ_AP027256:c503021-502647 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCCGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References