Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1799334..1799860 | Replicon | chromosome |
| Accession | NZ_AP027254 | ||
| Organism | Escherichia coli strain JNE120442 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QUE31_RS09095 | Protein ID | WP_000323025.1 |
| Coordinates | 1799334..1799621 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QUE31_RS09100 | Protein ID | WP_000534858.1 |
| Coordinates | 1799621..1799860 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE31_RS09045 (1794358) | 1794358..1794573 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| QUE31_RS09050 (1794793) | 1794793..1794963 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| QUE31_RS09055 (1795327) | 1795327..1795542 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| QUE31_RS09060 (1795843) | 1795843..1796055 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QUE31_RS09065 (1796110) | 1796110..1796199 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| QUE31_RS09070 (1796477) | 1796477..1797229 | - | 753 | WP_001047135.1 | antitermination protein | - |
| QUE31_RS09075 (1797243) | 1797243..1798292 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| QUE31_RS09080 (1798294) | 1798294..1798572 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| QUE31_RS09085 (1798639) | 1798639..1798890 | - | 252 | WP_000980994.1 | protein Rem | - |
| QUE31_RS09090 (1799107) | 1799107..1799262 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QUE31_RS09095 (1799334) | 1799334..1799621 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QUE31_RS09100 (1799621) | 1799621..1799860 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QUE31_RS09105 (1799885) | 1799885..1800190 | + | 306 | WP_001326990.1 | protein YdfV | - |
| QUE31_RS09110 (1800393) | 1800393..1800725 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| QUE31_RS09115 (1801162) | 1801162..1801311 | - | 150 | WP_011443592.1 | protein YdfW | - |
| QUE31_RS09120 (1801384) | 1801384..1802454 | - | 1071 | Protein_1786 | ISNCY family transposase | - |
| QUE31_RS09125 (1803244) | 1803244..1803531 | - | 288 | Protein_1787 | hypothetical protein | - |
| QUE31_RS09130 (1804009) | 1804009..1804498 | - | 490 | Protein_1788 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | stxB / stxA | 1763833..1889336 | 125503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T43590 WP_000323025.1 NZ_AP027254:c1799621-1799334 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T43590 NZ_AP027254:c1799621-1799334 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT43590 WP_000534858.1 NZ_AP027254:c1799860-1799621 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT43590 NZ_AP027254:c1799860-1799621 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|