Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1166307..1166778 | Replicon | chromosome |
| Accession | NZ_AP027246 | ||
| Organism | Escherichia coli strain JNE120393 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | QUF33_RS06235 | Protein ID | WP_001303511.1 |
| Coordinates | 1166500..1166778 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | QUF33_RS06230 | Protein ID | WP_001302048.1 |
| Coordinates | 1166307..1166498 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUF33_RS06180 (1161675) | 1161675..1161851 | - | 177 | WP_000753060.1 | hypothetical protein | - |
| QUF33_RS06185 (1161844) | 1161844..1162026 | - | 183 | WP_001224672.1 | hypothetical protein | - |
| QUF33_RS06190 (1162174) | 1162174..1162479 | - | 306 | WP_072094475.1 | DUF4406 domain-containing protein | - |
| QUF33_RS06195 (1162476) | 1162476..1162757 | - | 282 | WP_072094476.1 | DNA-binding protein | - |
| QUF33_RS06200 (1162790) | 1162790..1163506 | - | 717 | WP_028985606.1 | DUF1627 domain-containing protein | - |
| QUF33_RS06205 (1163540) | 1163540..1164001 | - | 462 | WP_000139447.1 | replication protein P | - |
| QUF33_RS06210 (1163994) | 1163994..1165025 | - | 1032 | WP_050868113.1 | DnaT-like ssDNA-binding domain-containing protein | - |
| QUF33_RS06215 (1165094) | 1165094..1165519 | - | 426 | WP_000693925.1 | toxin YdaT family protein | - |
| QUF33_RS06220 (1165516) | 1165516..1165818 | - | 303 | WP_032279888.1 | transcriptional regulator | - |
| QUF33_RS06225 (1165915) | 1165915..1166286 | + | 372 | WP_001169685.1 | hypothetical protein | - |
| QUF33_RS06230 (1166307) | 1166307..1166498 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| QUF33_RS06235 (1166500) | 1166500..1166778 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUF33_RS06240 (1167069) | 1167069..1167221 | + | 153 | WP_000367379.1 | DUF1391 family protein | - |
| QUF33_RS06245 (1167335) | 1167335..1167850 | - | 516 | WP_000559920.1 | hypothetical protein | - |
| QUF33_RS06250 (1168379) | 1168379..1168567 | + | 189 | WP_000450222.1 | cell division inhibition protein DicB | - |
| QUF33_RS06255 (1168564) | 1168564..1168752 | + | 189 | WP_000092784.1 | DUF1482 family protein | - |
| QUF33_RS06260 (1168845) | 1168845..1171289 | + | 2445 | WP_032284903.1 | exonuclease | - |
| QUF33_RS06265 (1171351) | 1171351..1171620 | + | 270 | WP_000003742.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | stx2B / stx2A | 1051093..1179876 | 128783 | |
| - | inside | Prophage | - | stx2B / stx2A | 1102380..1179876 | 77496 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T43568 WP_001303511.1 NZ_AP027246:1166500-1166778 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43568 NZ_AP027246:1166500-1166778 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43568 WP_001302048.1 NZ_AP027246:1166307-1166498 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43568 NZ_AP027246:1166307-1166498 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|