Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1782..2329 Replicon plasmid pJNE170426-2
Accession NZ_AP027219
Organism Escherichia coli strain JNE170426

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QUE10_RS25360 Protein ID WP_001384452.1
Coordinates 2051..2329 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag QUE10_RS25355 Protein ID WP_000079928.1
Coordinates 1782..2051 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE10_RS25345 (JNE170426_p20010) 1..873 + 873 WP_021553143.1 incFII family plasmid replication initiator RepA -
QUE10_RS25350 1569..1727 + 159 WP_032153484.1 hypothetical protein -
QUE10_RS25355 (JNE170426_p20020) 1782..2051 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QUE10_RS25360 (JNE170426_p20030) 2051..2329 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QUE10_RS25365 (JNE170426_p20040) 2375..3223 + 849 WP_021511698.1 3'-5' exonuclease -
QUE10_RS25370 3986..4612 + 627 WP_021511696.1 ProQ/FINO family protein -
QUE10_RS25375 (JNE170426_p20060) 4549..6135 + 1587 WP_244060170.1 UvrD-helicase domain-containing protein -
QUE10_RS25380 (JNE170426_p20070) 6246..6797 - 552 WP_001760564.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..86192 86192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T43557 WP_001384452.1 NZ_AP027219:2051-2329 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T43557 NZ_AP027219:2051-2329 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT43557 WP_000079928.1 NZ_AP027219:1782-2051 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT43557 NZ_AP027219:1782-2051 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCACGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References