Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4919449..4920247 Replicon chromosome
Accession NZ_AP027217
Organism Escherichia coli strain JNE170426

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X1M0U2
Locus tag QUE10_RS23965 Protein ID WP_000854919.1
Coordinates 4919870..4920247 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2G4AEZ5
Locus tag QUE10_RS23960 Protein ID WP_001285608.1
Coordinates 4919449..4919823 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE10_RS23925 (4916001) 4916001..4916678 + 678 WP_001097302.1 hypothetical protein -
QUE10_RS23930 (4916684) 4916684..4916917 + 234 WP_001278293.1 DUF905 family protein -
QUE10_RS23935 (4917007) 4917007..4917825 + 819 WP_001175165.1 DUF932 domain-containing protein -
QUE10_RS23940 (4917851) 4917851..4917991 - 141 WP_000997937.1 hypothetical protein -
QUE10_RS23945 (4918091) 4918091..4918570 + 480 WP_286347579.1 antirestriction protein -
QUE10_RS23950 (4918585) 4918585..4919061 + 477 WP_072647894.1 RadC family protein -
QUE10_RS23955 (4919148) 4919148..4919369 + 222 WP_000692350.1 DUF987 domain-containing protein -
QUE10_RS23960 (4919449) 4919449..4919823 + 375 WP_001285608.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
QUE10_RS23965 (4919870) 4919870..4920247 + 378 WP_000854919.1 TA system toxin CbtA family protein Toxin
QUE10_RS23970 (4920244) 4920244..4920732 + 489 WP_000777664.1 DUF5983 family protein -
QUE10_RS23975 (4920752) 4920752..4920949 + 198 WP_001327226.1 DUF957 domain-containing protein -
QUE10_RS23980 (4921034) 4921034..4921177 + 144 Protein_4670 hypothetical protein -
QUE10_RS23985 (4921621) 4921621..4921731 + 111 Protein_4671 DUF4102 domain-containing protein -
QUE10_RS23990 (4921835) 4921835..4922614 + 780 WP_001088806.1 HNH endonuclease -
QUE10_RS23995 (4922683) 4922683..4923060 + 378 WP_000784769.1 hypothetical protein -
QUE10_RS24000 (4923386) 4923386..4924684 + 1299 Protein_4674 AAA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage fosA7 fimB / fimE 4912425..4934053 21628


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14037.97 Da        Isoelectric Point: 7.9086

>T43555 WP_000854919.1 NZ_AP027217:4919870-4920247 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T43555 NZ_AP027217:4919870-4920247 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13610.37 Da        Isoelectric Point: 5.5051

>AT43555 WP_001285608.1 NZ_AP027217:4919449-4919823 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Download         Length: 375 bp

>AT43555 NZ_AP027217:4919449-4919823 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACTCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1M0U2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4AEZ5

References