Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4170037..4170869 Replicon chromosome
Accession NZ_AP027217
Organism Escherichia coli strain JNE170426

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag QUE10_RS20370 Protein ID WP_000854753.1
Coordinates 4170495..4170869 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag QUE10_RS20365 Protein ID WP_001280951.1
Coordinates 4170037..4170405 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE10_RS20335 (4166867) 4166867..4167322 + 456 WP_000581504.1 IrmA family protein -
QUE10_RS20340 (4167401) 4167401..4167634 + 234 WP_001119729.1 DUF905 family protein -
QUE10_RS20345 (4167734) 4167734..4168552 + 819 WP_001234620.1 DUF932 domain-containing protein -
QUE10_RS20350 (4168607) 4168607..4169092 + 486 WP_001469549.1 antirestriction protein -
QUE10_RS20355 (4169108) 4169108..4169584 + 477 WP_001186724.1 RadC family protein -
QUE10_RS20360 (4169653) 4169653..4169874 + 222 WP_001405861.1 DUF987 domain-containing protein -
QUE10_RS20365 (4170037) 4170037..4170405 + 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QUE10_RS20370 (4170495) 4170495..4170869 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
QUE10_RS20375 (4170866) 4170866..4171354 + 489 WP_001549830.1 DUF5983 family protein -
QUE10_RS20380 (4171366) 4171366..4171563 + 198 WP_000839243.1 DUF957 domain-containing protein -
QUE10_RS20385 (4171648) 4171648..4172493 + 846 WP_001406222.1 DUF4942 domain-containing protein -
QUE10_RS20390 (4172728) 4172728..4172889 + 162 Protein_3984 RhuM family protein -
QUE10_RS20395 (4173286) 4173286..4174470 + 1185 WP_001172876.1 sugar efflux transporter -
QUE10_RS20400 (4174581) 4174581..4175504 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T43551 WP_000854753.1 NZ_AP027217:4170495-4170869 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T43551 NZ_AP027217:4170495-4170869 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT43551 WP_001280951.1 NZ_AP027217:4170037-4170405 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT43551 NZ_AP027217:4170037-4170405 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References