Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1278070..1278541 | Replicon | chromosome |
| Accession | NZ_AP027212 | ||
| Organism | Escherichia coli strain JNE131328 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | QUE42_RS06150 | Protein ID | WP_001303511.1 |
| Coordinates | 1278070..1278348 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | QUE42_RS06155 | Protein ID | WP_001302048.1 |
| Coordinates | 1278350..1278541 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE42_RS06120 (1273228) | 1273228..1273497 | - | 270 | WP_000003742.1 | excisionase | - |
| QUE42_RS06125 (1273559) | 1273559..1276003 | - | 2445 | WP_032284903.1 | exonuclease | - |
| QUE42_RS06130 (1276096) | 1276096..1276284 | - | 189 | WP_000092784.1 | DUF1482 family protein | - |
| QUE42_RS06135 (1276281) | 1276281..1276469 | - | 189 | WP_000450222.1 | cell division inhibition protein DicB | - |
| QUE42_RS06140 (1276998) | 1276998..1277513 | + | 516 | WP_000559920.1 | hypothetical protein | - |
| QUE42_RS06145 (1277627) | 1277627..1277779 | - | 153 | WP_000367379.1 | DUF1391 family protein | - |
| QUE42_RS06150 (1278070) | 1278070..1278348 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE42_RS06155 (1278350) | 1278350..1278541 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| QUE42_RS06160 (1278562) | 1278562..1278933 | - | 372 | WP_001169685.1 | hypothetical protein | - |
| QUE42_RS06165 (1279030) | 1279030..1279332 | + | 303 | WP_032279888.1 | transcriptional regulator | - |
| QUE42_RS06170 (1279329) | 1279329..1279754 | + | 426 | WP_000693925.1 | toxin YdaT family protein | - |
| QUE42_RS06175 (1279823) | 1279823..1280860 | + | 1038 | WP_032284491.1 | DnaT-like ssDNA-binding domain-containing protein | - |
| QUE42_RS06180 (1280853) | 1280853..1281314 | + | 462 | WP_000139468.1 | replication protein P | - |
| QUE42_RS06185 (1281348) | 1281348..1282064 | + | 717 | WP_028985606.1 | DUF1627 domain-containing protein | - |
| QUE42_RS06190 (1282097) | 1282097..1282378 | + | 282 | WP_072094476.1 | DNA-binding protein | - |
| QUE42_RS06195 (1282375) | 1282375..1282680 | + | 306 | WP_072094475.1 | DUF4406 domain-containing protein | - |
| QUE42_RS06200 (1282828) | 1282828..1283010 | + | 183 | WP_001224672.1 | hypothetical protein | - |
| QUE42_RS06205 (1283003) | 1283003..1283179 | + | 177 | WP_000753060.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | stx2A / stx2B | 1267873..1393770 | 125897 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T43508 WP_001303511.1 NZ_AP027212:c1278348-1278070 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T43508 NZ_AP027212:c1278348-1278070 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT43508 WP_001302048.1 NZ_AP027212:c1278541-1278350 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT43508 NZ_AP027212:c1278541-1278350 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|