Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1509615..1510252 Replicon chromosome
Accession NZ_AP027204
Organism Polynucleobacter sp. SHI8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMN06_RS07575 Protein ID WP_281971747.1
Coordinates 1509615..1510013 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMN06_RS07580 Protein ID WP_281969524.1
Coordinates 1510013..1510252 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN06_RS07540 (PSHI8_14760) 1505542..1506312 + 771 WP_281969518.1 substrate-binding domain-containing protein -
QMN06_RS07545 (PSHI8_14770) 1506363..1506752 - 390 WP_281969519.1 50S ribosomal protein L19 -
QMN06_RS07550 (PSHI8_14780) 1506834..1507580 - 747 WP_281971746.1 tRNA (guanosine(37)-N1)-methyltransferase TrmD -
QMN06_RS07555 (PSHI8_14790) 1507588..1508115 - 528 WP_281969520.1 ribosome maturation factor RimM -
QMN06_RS07560 (PSHI8_14800) 1508155..1508409 - 255 WP_281969521.1 30S ribosomal protein S16 -
QMN06_RS07565 1508557..1509078 + 522 WP_281969522.1 META domain-containing protein -
QMN06_RS07570 (PSHI8_14820) 1509140..1509589 + 450 WP_281969523.1 NINE protein -
QMN06_RS07575 (PSHI8_14830) 1509615..1510013 - 399 WP_281971747.1 tRNA(fMet)-specific endonuclease VapC Toxin
QMN06_RS07580 (PSHI8_14840) 1510013..1510252 - 240 WP_281969524.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QMN06_RS07585 (PSHI8_14850) 1510480..1512267 - 1788 WP_281969525.1 acyl-CoA dehydrogenase -
QMN06_RS07590 (PSHI8_14860) 1512292..1513230 - 939 WP_281969526.1 FAD-binding protein -
QMN06_RS07595 (PSHI8_14870) 1513231..1513980 - 750 WP_281969527.1 electron transfer flavoprotein subunit beta/FixA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15129.37 Da        Isoelectric Point: 6.4844

>T43480 WP_281971747.1 NZ_AP027204:c1510013-1509615 [Polynucleobacter sp. SHI8]
ILKYMLDTNIVIYVLKRRPIQVLDIFNQNTNRMAISSITLSELIYGAEKSQNISKNLDAIEDFISHIEVLSYDQKTSQTY
GQIKAKLEKNGEIIGENDIHIAAHAISQGLILVTNNLYEFRRVPHLSLENWV

Download         Length: 399 bp

>T43480 NZ_AP027204:c1510013-1509615 [Polynucleobacter sp. SHI8]
ATATTGAAATACATGCTTGACACGAATATAGTGATTTATGTTCTAAAGAGAAGGCCTATTCAAGTACTGGATATATTTAA
TCAAAATACTAATCGAATGGCGATTTCCAGCATCACACTTTCGGAATTAATTTATGGTGCAGAAAAAAGTCAAAATATTA
GTAAAAATCTAGATGCTATTGAGGATTTTATAAGTCATATTGAAGTACTTTCATATGATCAAAAGACTTCTCAAACATAT
GGTCAAATTAAAGCAAAACTTGAAAAAAATGGAGAAATAATTGGTGAAAATGATATTCACATTGCGGCCCATGCTATCAG
CCAAGGTTTAATACTAGTAACAAATAATTTATATGAGTTTCGGAGAGTTCCTCATTTATCTCTAGAAAATTGGGTGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9102.45 Da        Isoelectric Point: 10.5888

>AT43480 WP_281969524.1 NZ_AP027204:c1510252-1510013 [Polynucleobacter sp. SHI8]
MKITLSTVFTNNRTQAVRLPAEARLPDDVKKVAVRIRGKDRIISPIENTWDHFFLIGPTVTEDFMNDRGVQKNSLRESF

Download         Length: 240 bp

>AT43480 NZ_AP027204:c1510252-1510013 [Polynucleobacter sp. SHI8]
ATGAAAATAACTCTGTCTACTGTTTTTACTAATAATAGGACGCAAGCTGTTCGCCTCCCAGCTGAAGCTCGCCTTCCAGA
TGATGTAAAAAAAGTGGCTGTAAGGATTAGAGGTAAAGATCGCATTATTTCTCCTATTGAAAATACTTGGGATCATTTCT
TTTTAATTGGTCCCACTGTTACCGAAGATTTTATGAATGATCGTGGGGTACAAAAAAATTCATTAAGAGAGAGTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References