Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1509613..1510250 Replicon chromosome
Accession NZ_AP027203
Organism Polynucleobacter sp. SHI2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMN13_RS07575 Protein ID WP_281971747.1
Coordinates 1509613..1510011 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QMN13_RS07580 Protein ID WP_281969524.1
Coordinates 1510011..1510250 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN13_RS07540 (PSHI2_14750) 1505540..1506310 + 771 WP_281969518.1 substrate-binding domain-containing protein -
QMN13_RS07545 (PSHI2_14760) 1506361..1506750 - 390 WP_281969519.1 50S ribosomal protein L19 -
QMN13_RS07550 (PSHI2_14770) 1506832..1507578 - 747 WP_281971746.1 tRNA (guanosine(37)-N1)-methyltransferase TrmD -
QMN13_RS07555 (PSHI2_14780) 1507586..1508113 - 528 WP_281969520.1 ribosome maturation factor RimM -
QMN13_RS07560 (PSHI2_14790) 1508153..1508407 - 255 WP_281969521.1 30S ribosomal protein S16 -
QMN13_RS07565 1508555..1509076 + 522 WP_281969522.1 META domain-containing protein -
QMN13_RS07570 (PSHI2_14810) 1509138..1509587 + 450 WP_281969523.1 NINE protein -
QMN13_RS07575 (PSHI2_14820) 1509613..1510011 - 399 WP_281971747.1 tRNA(fMet)-specific endonuclease VapC Toxin
QMN13_RS07580 (PSHI2_14830) 1510011..1510250 - 240 WP_281969524.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QMN13_RS07585 (PSHI2_14840) 1510478..1512265 - 1788 WP_281969525.1 acyl-CoA dehydrogenase -
QMN13_RS07590 (PSHI2_14850) 1512290..1513228 - 939 WP_281969526.1 FAD-binding protein -
QMN13_RS07595 (PSHI2_14860) 1513229..1513978 - 750 WP_281969527.1 electron transfer flavoprotein subunit beta/FixA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15129.37 Da        Isoelectric Point: 6.4844

>T43476 WP_281971747.1 NZ_AP027203:c1510011-1509613 [Polynucleobacter sp. SHI2]
ILKYMLDTNIVIYVLKRRPIQVLDIFNQNTNRMAISSITLSELIYGAEKSQNISKNLDAIEDFISHIEVLSYDQKTSQTY
GQIKAKLEKNGEIIGENDIHIAAHAISQGLILVTNNLYEFRRVPHLSLENWV

Download         Length: 399 bp

>T43476 NZ_AP027203:c1510011-1509613 [Polynucleobacter sp. SHI2]
ATATTGAAATACATGCTTGACACGAATATAGTGATTTATGTTCTAAAGAGAAGGCCTATTCAAGTACTGGATATATTTAA
TCAAAATACTAATCGAATGGCGATTTCCAGCATCACACTTTCGGAATTAATTTATGGTGCAGAAAAAAGTCAAAATATTA
GTAAAAATCTAGATGCTATTGAGGATTTTATAAGTCATATTGAAGTACTTTCATATGATCAAAAGACTTCTCAAACATAT
GGTCAAATTAAAGCAAAACTTGAAAAAAATGGAGAAATAATTGGTGAAAATGATATTCACATTGCGGCCCATGCTATCAG
CCAAGGTTTAATACTAGTAACAAATAATTTATATGAGTTTCGGAGAGTTCCTCATTTATCTCTAGAAAATTGGGTGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9102.45 Da        Isoelectric Point: 10.5888

>AT43476 WP_281969524.1 NZ_AP027203:c1510250-1510011 [Polynucleobacter sp. SHI2]
MKITLSTVFTNNRTQAVRLPAEARLPDDVKKVAVRIRGKDRIISPIENTWDHFFLIGPTVTEDFMNDRGVQKNSLRESF

Download         Length: 240 bp

>AT43476 NZ_AP027203:c1510250-1510011 [Polynucleobacter sp. SHI2]
ATGAAAATAACTCTGTCTACTGTTTTTACTAATAATAGGACGCAAGCTGTTCGCCTCCCAGCTGAAGCTCGCCTTCCAGA
TGATGTAAAAAAAGTGGCTGTAAGGATTAGAGGTAAAGATCGCATTATTTCTCCTATTGAAAATACTTGGGATCATTTCT
TTTTAATTGGTCCCACTGTTACCGAAGATTTTATGAATGATCGTGGGGTACAAAAAAATTCATTAAGAGAGAGTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References