Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 98204..99719 Replicon chromosome
Accession NZ_AP027203
Organism Polynucleobacter sp. SHI2

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag QMN13_RS00550 Protein ID WP_281970547.1
Coordinates 98204..99490 (-) Length 429 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag QMN13_RS00555 Protein ID WP_281970548.1
Coordinates 99480..99719 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN13_RS00545 (PSHI2_00980) 96717..98180 + 1464 WP_281970546.1 glutamate synthase subunit beta -
QMN13_RS00550 (PSHI2_00990) 98204..99490 - 1287 WP_281970547.1 type II toxin-antitoxin system HipA family toxin Toxin
QMN13_RS00555 (PSHI2_01000) 99480..99719 - 240 WP_281970548.1 helix-turn-helix transcriptional regulator Antitoxin
QMN13_RS00560 (PSHI2_01010) 99902..100711 + 810 WP_281970549.1 cyclase family protein -
QMN13_RS00565 (PSHI2_01020) 100761..101588 + 828 WP_281970550.1 ABC transporter ATP-binding protein -
QMN13_RS00570 (PSHI2_01030) 101588..102376 + 789 WP_281971693.1 lipid asymmetry maintenance ABC transporter permease subunit MlaE -
QMN13_RS00575 (PSHI2_01040) 102404..102877 + 474 WP_281970552.1 outer membrane lipid asymmetry maintenance protein MlaD -
QMN13_RS00580 (PSHI2_01050) 102880..103665 + 786 WP_281970554.1 VacJ family lipoprotein -
QMN13_RS00585 (PSHI2_01060) 103790..104389 + 600 WP_281971694.1 ABC transporter substrate-binding protein -
QMN13_RS00590 (PSHI2_01070) 104389..104652 + 264 WP_281970555.1 STAS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-66)


Sequences

Toxin        


Download         Length: 429 a.a.        Molecular weight: 48037.33 Da        Isoelectric Point: 7.4126

>T43473 WP_281970547.1 NZ_AP027203:c99490-98204 [Polynucleobacter sp. SHI2]
MESNTLAVWLFNHLVGYLSLDKGKLSFCYTSDWLSDIHAQPLSHSLPLQEKVFDDNLARPFFSGLLPEGRPRRLIAKEFH
ISLQNDFSLLDIIGGECAGAVSFIRPQEKLLSPHLNDASKNIKWLSESELLHTLEELPLRPMLAGDGEGYRLSLAGAQDK
LPVVYDGHRIGLPLHGMPSSHILKPTILAVNDSVTNEGFCMALAKLMQLQPANAIIEQVQGVRFLLVERYDRVKNSDGIL
HRLHQEDFCQALGCVPEMKYQNEGGPSLGQCFDFLRNTTNPHAPQLLRFFDYVVFNTLIGNHDAHGKNFSLLYDGKVATL
APLYDALCTAVYPKLTSKMAMKIGSKYKFSEIHMRHWDELLDSAKLNKSQGKKHIISIAKRLVIQAKDLQSNPHAGFSNN
DIVNQIVNLIEQRCSLTIKRLSIHAPQE

Download         Length: 1287 bp

>T43473 NZ_AP027203:c99490-98204 [Polynucleobacter sp. SHI2]
ATGGAGAGTAATACATTAGCCGTTTGGTTGTTTAATCACCTAGTTGGTTACTTATCTTTGGATAAAGGAAAACTCAGTTT
TTGTTATACGTCTGATTGGTTAAGTGACATTCATGCTCAACCTCTGTCCCACTCACTGCCATTGCAAGAGAAGGTTTTCG
ACGATAACTTAGCTCGCCCTTTTTTTTCTGGTTTACTTCCAGAAGGACGCCCACGTCGACTTATTGCGAAAGAATTCCAT
ATTTCGCTTCAAAACGATTTTTCTTTACTAGACATCATTGGTGGTGAGTGTGCAGGTGCAGTGAGCTTTATCAGGCCCCA
AGAAAAATTACTGTCACCTCATTTAAATGATGCTTCGAAAAATATTAAATGGCTAAGCGAATCAGAACTACTTCACACCT
TAGAAGAGTTACCCCTTCGACCCATGCTTGCGGGTGATGGAGAAGGCTATCGACTTTCACTTGCTGGAGCTCAAGACAAA
CTACCGGTAGTTTATGATGGCCATCGAATCGGTTTGCCTCTGCATGGCATGCCGAGTTCTCATATTTTGAAACCAACCAT
TCTTGCGGTAAATGATAGTGTTACCAATGAAGGGTTTTGCATGGCTTTAGCAAAATTGATGCAACTTCAACCCGCAAACG
CCATCATTGAGCAAGTTCAAGGAGTTCGATTTTTGCTGGTTGAGCGTTACGATCGTGTCAAGAATTCTGATGGCATCTTA
CATCGCTTACATCAAGAAGATTTTTGTCAAGCATTGGGCTGCGTTCCTGAAATGAAATATCAAAATGAAGGTGGCCCAAG
CCTGGGACAATGTTTTGATTTTTTACGAAACACTACAAACCCTCATGCGCCTCAATTACTGCGATTTTTTGACTATGTTG
TCTTTAATACACTTATTGGCAATCATGATGCTCATGGGAAAAATTTCTCGCTTCTTTACGATGGTAAAGTAGCTACTTTG
GCGCCACTCTATGATGCTCTATGCACAGCGGTTTATCCAAAACTTACCTCAAAAATGGCCATGAAAATCGGTAGTAAATA
TAAATTTAGCGAGATTCATATGAGGCATTGGGATGAATTATTAGACAGCGCTAAGCTCAATAAGTCACAAGGTAAAAAAC
ACATTATTAGTATTGCAAAAAGGCTCGTCATTCAAGCTAAAGATTTGCAATCAAATCCCCATGCAGGATTTTCTAATAAT
GACATTGTGAATCAAATTGTTAACTTAATCGAACAAAGATGCTCATTAACTATTAAGCGTCTGAGCATTCATGCGCCACA
AGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8346.87 Da        Isoelectric Point: 10.1886

>AT43473 WP_281970548.1 NZ_AP027203:c99719-99480 [Polynucleobacter sp. SHI2]
MAMVKMESSSQIGNAVRLARKKLALTQPQLALAAGVGVRFIVDLEAGKPTIQLERMLQVLHALGGDIHIGGLKGLNDGE

Download         Length: 240 bp

>AT43473 NZ_AP027203:c99719-99480 [Polynucleobacter sp. SHI2]
ATGGCAATGGTAAAAATGGAGTCCTCCTCACAAATCGGAAACGCAGTGCGATTGGCGCGCAAGAAACTCGCTTTGACTCA
ACCCCAGTTAGCTTTAGCAGCTGGTGTAGGTGTCCGGTTTATTGTTGATTTAGAGGCTGGGAAACCGACGATACAACTCG
AACGTATGCTTCAAGTATTACACGCTTTAGGTGGCGACATTCATATCGGTGGCCTTAAAGGTTTAAACGATGGAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References